Abstract
The European multicentre trial, carried out from 1985 to1987, was the first large-scale investigation of the efficacy of Curosurf [1]. This trial involved eight neonatal units in six countries (table 1). One-hundred and forty-six babies were enrolled, 77 receiving Curosurf and 69 acting as controls. Entry criteria included birth weight 700–2000 g, age 2–15 h at randomization, clinical and radiological evidence of RDS and a requirement for mechanical ventilation with at least 60% oxygen. After randomization, treated babies were given a single dose of Curosurf (equivalent to 200 mg/kg of phospholipid) via the endotracheal tube, followed by 2 min of manual ventilation. Control babies did not receive a placebo but were also manually ventilated for 2 min [1].
Preview
Unable to display preview. Download preview PDF.
References
Collaborative European Multicenter Study Group. Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Pediatrics 1988; 82: 683–91.
Notter, R. H., Egan, E. A., Kwong, M. S., Holm, B. A. and Shapiro, D. L. Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique and gestational age. Pediatr Res 1985; 19: 569–77.
Tubman, T. R. J. and Halliday, H. L. Surfactant treatment for severe respiratory distress syndrome following very prolonged rupture of membranes. Eur J Pediatr 1990; 149: 727–9.
Fujiwara, T., Konishi, M., Chida, S. and Maeta, H. Factors affecting the response to a postnatal single dose of a reconstituted bovine surfactant (surfactant TA). In: Lachmann, B., ed. Surfactant Replacement Therapy in Neonatal and Adult Respiratory Distress Syndrome, Berlin: Springer-Verlag, 1988; 91–107.
Robertson, B. Short term clinical response and follow up in 164 babies treated with porcine surfactant (Curosurf) for severe neonatal respiratory distress syndrome (RDS) (Abstract). Pediatr Res 1989; 26: 512.
McCord, F. B., Halliday, H. L., McClure, B. G. and Reid M. McC. Changes in pulmonary and cerebral blood flow after surfactant treatment of severe respiratory distress syndrome. In: Lachmann, B., ed. Surfactant Replacement Therapy in Neonatal and Adult Respiratory Distress Syndrome, Berlin: Springer-Verlag, 1988; 195–200.
Tubman, T. R. J. and Halliday, H. L. Effect of surfactant replacement therapy on dynamic compliance of the respiratory system (Cdyn) in neonatal respiratory distress syndrome (Abstract G113). In: Proceedings of the 62nd Annual Meeting of the British Paediatric Association (Warwick), London: British Paediatric Association, 1990; 74.
Jobe, A., Jacobs, H., Ikegami, M. and Jones, S. Cardiovascular effects of surfactant suspensions given by tracheal instillation to premature lambs. Pediatr Res 1983; 17: 444–8.
Heldt, G. P., Pesonen, E., Merritt, A., Elias, W. and Sahn D. J. Closure of the ductus arteriosus and mechanics of breathing in preterm infants after surfactant replacement therapy. Pediatr Res 1989; 25: 305–10.
Groneck, P. Changes of pulmonary mechanics following Curosurf replacement. In: Speer, C. P. and Robertson, B., eds. Proceedings of the 4th Workshop on Surfactant Replacement(Hardenburg), Gottingen: University of Gottingen, 1989; 17–29.
Wieseman, H. G., Hanssler, L. and Stassen, W. Pulmonary mechanics and ventilation in premature infants after surfactant treatment. In: Speer, C. P. and Robertson, B., eds. Proceedings of the 4th Workshop on Surfactant Replacement (Hardenburg), Gottingen: University of Gottingen, 1989; 30.
Fujiwara, T., Maeta, H., Chida, S., Morita, T., Watabe, Y. and Abe, T. Artificial surfactant therapy in hyaline membrane disease. Lancet1980; is 55–9.
Hallman, M., Merritt, T. A., Jarvenpaa, A. L., Boynton, B., Mannino, F. et al. Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized, prospective clinical trial. J Pediatr 1985; 106: 963–9.
Enhorning, G. E., Shennan, A., Possmayer, F., Dunn, M., Chen, C. P. and Milligan, J. Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant. A randomized clinical trial. Pediatrics 1985; 76: 145–53.
Shapiro, D. L., Notter, R. H., Morin, F. C., Deluga, K. S., Golub, L. M., Sinkin, R. A. et al. A double-blind randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of the respiratory distress syndrome. Pediatrics1985; 76: 593–9.
Halliday, H. L. Clinical experience with exogenous natural surfactant. Dey Pharmacol Ther 1989; 13: 173–81.
Halliday, H. L., McClure, B. G., Reid, M., McCord, B. and Sittlington, N. Experienr e with Curosurf for the treatment of severe respiratory distress syndrome: the European Multicentre Study and studies in Belfast. In: Grauel, E. L., Stern, L., Syllm-Rapoport, I. and Wauer, R. L., eds. Research in Perinatal Medicine II: An Interdisciplinary Approach with Special Emphasis on Epidemiology, Surfactant and Infections, Berlin, Verlag Gesundheit GmbH, 1990; 89–97.
Tubman, T. R. J., Normand, C. and Halliday, H. L. Cost of surfactant replacement for severe neonatal respiratory distress syndrome (RDS): results of a randomized controlled trial (Abstract G170). In: Proceedings of the 62nd Annual Meeting of the British Paediatric Association (Warwick), London: British Paediatric Association, 1990: 89.
Editor information
Editors and Affiliations
Copyright information
© 1991 Macmillan Publishers Limited
About this chapter
Cite this chapter
Halliday, H.L., Tubman, T.R.J. (1991). Further experiences with Curosurf in Europe. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_18
Download citation
DOI: https://doi.org/10.1007/978-1-349-12553-1_18
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-12555-5
Online ISBN: 978-1-349-12553-1
eBook Packages: EngineeringEngineering (R0)