Skip to main content
SpringerLink
Log in
Book cover

The Surfactant System of the Lung pp 112–121Cite as

Further experiences with Curosurf in Europe

  • Chapter

  • 17 Accesses

Abstract

The European multicentre trial, carried out from 1985 to1987, was the first large-scale investigation of the efficacy of Curosurf [1]. This trial involved eight neonatal units in six countries (table 1). One-hundred and forty-six babies were enrolled, 77 receiving Curosurf and 69 acting as controls. Entry criteria included birth weight 700–2000 g, age 2–15 h at randomization, clinical and radiological evidence of RDS and a requirement for mechanical ventilation with at least 60% oxygen. After randomization, treated babies were given a single dose of Curosurf (equivalent to 200 mg/kg of phospholipid) via the endotracheal tube, followed by 2 min of manual ventilation. Control babies did not receive a placebo but were also manually ventilated for 2 min [1].

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Collaborative European Multicenter Study Group. Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Pediatrics 1988; 82: 683–91.

    Google Scholar 

  2. Notter, R. H., Egan, E. A., Kwong, M. S., Holm, B. A. and Shapiro, D. L. Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique and gestational age. Pediatr Res 1985; 19: 569–77.

    Article  Google Scholar 

  3. Tubman, T. R. J. and Halliday, H. L. Surfactant treatment for severe respiratory distress syndrome following very prolonged rupture of membranes. Eur J Pediatr 1990; 149: 727–9.

    Article  Google Scholar 

  4. Fujiwara, T., Konishi, M., Chida, S. and Maeta, H. Factors affecting the response to a postnatal single dose of a reconstituted bovine surfactant (surfactant TA). In: Lachmann, B., ed. Surfactant Replacement Therapy in Neonatal and Adult Respiratory Distress Syndrome, Berlin: Springer-Verlag, 1988; 91–107.

    Google Scholar 

  5. Robertson, B. Short term clinical response and follow up in 164 babies treated with porcine surfactant (Curosurf) for severe neonatal respiratory distress syndrome (RDS) (Abstract). Pediatr Res 1989; 26: 512.

    Article  Google Scholar 

  6. McCord, F. B., Halliday, H. L., McClure, B. G. and Reid M. McC. Changes in pulmonary and cerebral blood flow after surfactant treatment of severe respiratory distress syndrome. In: Lachmann, B., ed. Surfactant Replacement Therapy in Neonatal and Adult Respiratory Distress Syndrome, Berlin: Springer-Verlag, 1988; 195–200.

    Google Scholar 

  7. Tubman, T. R. J. and Halliday, H. L. Effect of surfactant replacement therapy on dynamic compliance of the respiratory system (Cdyn) in neonatal respiratory distress syndrome (Abstract G113). In: Proceedings of the 62nd Annual Meeting of the British Paediatric Association (Warwick), London: British Paediatric Association, 1990; 74.

    Google Scholar 

  8. Jobe, A., Jacobs, H., Ikegami, M. and Jones, S. Cardiovascular effects of surfactant suspensions given by tracheal instillation to premature lambs. Pediatr Res 1983; 17: 444–8.

    Article  Google Scholar 

  9. Heldt, G. P., Pesonen, E., Merritt, A., Elias, W. and Sahn D. J. Closure of the ductus arteriosus and mechanics of breathing in preterm infants after surfactant replacement therapy. Pediatr Res 1989; 25: 305–10.

    Article  Google Scholar 

  10. Groneck, P. Changes of pulmonary mechanics following Curosurf replacement. In: Speer, C. P. and Robertson, B., eds. Proceedings of the 4th Workshop on Surfactant Replacement(Hardenburg), Gottingen: University of Gottingen, 1989; 17–29.

    Google Scholar 

  11. Wieseman, H. G., Hanssler, L. and Stassen, W. Pulmonary mechanics and ventilation in premature infants after surfactant treatment. In: Speer, C. P. and Robertson, B., eds. Proceedings of the 4th Workshop on Surfactant Replacement (Hardenburg), Gottingen: University of Gottingen, 1989; 30.

    Google Scholar 

  12. Fujiwara, T., Maeta, H., Chida, S., Morita, T., Watabe, Y. and Abe, T. Artificial surfactant therapy in hyaline membrane disease. Lancet1980; is 55–9.

    Google Scholar 

  13. Hallman, M., Merritt, T. A., Jarvenpaa, A. L., Boynton, B., Mannino, F. et al. Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized, prospective clinical trial. J Pediatr 1985; 106: 963–9.

    Article  Google Scholar 

  14. Enhorning, G. E., Shennan, A., Possmayer, F., Dunn, M., Chen, C. P. and Milligan, J. Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant. A randomized clinical trial. Pediatrics 1985; 76: 145–53.

    Google Scholar 

  15. Shapiro, D. L., Notter, R. H., Morin, F. C., Deluga, K. S., Golub, L. M., Sinkin, R. A. et al. A double-blind randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of the respiratory distress syndrome. Pediatrics1985; 76: 593–9.

    Google Scholar 

  16. Halliday, H. L. Clinical experience with exogenous natural surfactant. Dey Pharmacol Ther 1989; 13: 173–81.

    Google Scholar 

  17. Halliday, H. L., McClure, B. G., Reid, M., McCord, B. and Sittlington, N. Experienr e with Curosurf for the treatment of severe respiratory distress syndrome: the European Multicentre Study and studies in Belfast. In: Grauel, E. L., Stern, L., Syllm-Rapoport, I. and Wauer, R. L., eds. Research in Perinatal Medicine II: An Interdisciplinary Approach with Special Emphasis on Epidemiology, Surfactant and Infections, Berlin, Verlag Gesundheit GmbH, 1990; 89–97.

    Google Scholar 

  18. Tubman, T. R. J., Normand, C. and Halliday, H. L. Cost of surfactant replacement for severe neonatal respiratory distress syndrome (RDS): results of a randomized controlled trial (Abstract G170). In: Proceedings of the 62nd Annual Meeting of the British Paediatric Association (Warwick), London: British Paediatric Association, 1990: 89.

    Google Scholar 

Download references

Authors
  1. H. L. Halliday
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. R. J. Tubman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Second Institute of Gynaecology and Obstetrics, University of La Sapienza, Rome, Italy

    E. V. Cosmi

  2. Institute of Gynaecology and Obstetrics, University of Perugia, Policlinico Monteluce, Perugia, Italy

    G. C. Di Renzo

  3. Second Institute of Gynaecology and Obstetrics, University of La Sapienza, Rome, Italy

    M. M. Anceschi

Copyright information

© 1991 Macmillan Publishers Limited

About this chapter

Cite this chapter

Halliday, H.L., Tubman, T.R.J. (1991). Further experiences with Curosurf in Europe. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-12553-1_18

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-12555-5

  • Online ISBN: 978-1-349-12553-1

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation