Abstract
The European multicentre trial, carried out from 1985 to1987, was the first large-scale investigation of the efficacy of Curosurf [1]. This trial involved eight neonatal units in six countries (table 1). One-hundred and forty-six babies were enrolled, 77 receiving Curosurf and 69 acting as controls. Entry criteria included birth weight 700–2000 g, age 2–15 h at randomization, clinical and radiological evidence of RDS and a requirement for mechanical ventilation with at least 60% oxygen. After randomization, treated babies were given a single dose of Curosurf (equivalent to 200 mg/kg of phospholipid) via the endotracheal tube, followed by 2 min of manual ventilation. Control babies did not receive a placebo but were also manually ventilated for 2 min [1].
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© 1991 Macmillan Publishers Limited
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Halliday, H.L., Tubman, T.R.J. (1991). Further experiences with Curosurf in Europe. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_18
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DOI: https://doi.org/10.1007/978-1-349-12553-1_18
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