Abstract
The functional immaturity of lung in preterm babies leads to an acute progressive breathing failure, the so-called hyaline membrane disease (HMD). In the last few years, neonatal mortality for HMD, approximately 1.5%, has greatly decreased with skilled nursing and physician management, but it still represents a major cause of mortality [1]. An important point is its prevention, inducing fetal lung maturation in utero by means of drugs administered to the mother [2] and developing surfactant substitutes for the treatment of surfactant deficiency at birth or following the development of HMD [3,4]. As preterm newborn infants of gestational age <33 weeks are a high-risk group for developing HMD, we analyse the survival of very-low-birth-weight (VLBW) infants with respect to both antepartum maternal administration of Ambroxol and severity of HMD.
This is a preview of subscription content, log in via an institution.
Preview
Unable to display preview. Download preview PDF.
References
Stahlman, M. T. The history of HMD and development of its concepts. In: Stern, L., ed. HMD, Orlando: Grune and Stratton, 1984; 1–15.
Di Renzo, G. C., Anceschi, M. M., Guidetti, R. and Cosmi, E. V. Requirements of perinatal prevention and treatment of respiratory distress syndrome. Eur Respir J 1989; 2: Suppl. 3, 68–72S.
Avery, M. E., Taeusch, H. W. and Floros, J. Surfactant replacement. New Engl J Med 1986; 315: 825–6.
Collaborative European Multicenter Study Group. Surfactant replacement therapy for severe neonatal respiratory distress syndrome; an international randomized clinical study. Pediatrics 1988; 82: 683–91.
Hjalmarson, O. Epidemiology and classification of acute neonatal respiratory disorders. A prospective study. Acta Pediatr Scand 1981; 70: 773–83.
Taeusch, H. W., Frigoletto, F., Kitzmiller, J., Avery, M. E., Henre, A. and Neff, R. Risk of RDS after prenatal dexamethasone treatment. Pediatrics 1989; 63: 64–72.
Verloove-Van Horick, S. P. and Verwey, R. A. Project on preterm and small for gestational age preterm infants in the Netherlands 1983. POPS, Pasmans, Gravenhage, 1987.
Wauer, R. R., Hengst, P. and Grauel, E. L. Prenatal prophylaxis of HMD with prednisolone: advantages and disadvantages. Biol Res Preg 1983; 4: 113–19.
Quirk, J. G. Risks and benefits of steroid therapy for prevention of HMD. In: Grauel, E. L., Syllm-Rapoport, I. and Wauer, R. R. eds. Research in Perinatal Medicine, Leipzig: Thieme, 1986; 86–93.
Lazzarin, A., Capsoni, F., Luerti, M., Uberti Foppa, C., Galli, M. and Zavattini, I. G. Immunological characteristics of preterm neonates after prophylaxis of RDS. In Vignali, M., Cosmi, E. V. and Luerti, M., eds. Diagnosis and Treatment of Fetal Lung Immaturity, Milan: Masson, 1986; 134–9.
Lachmann, B., Tischer, A. B., Grossmann, G. and Robertson, B. Lung compliance and alveolar expansion in the artificially ventilated premature newborn rabbit after maternal treatment with ambroxol. ?? 1981; 42: 209–16.
Velasquez, B. J. and Sepulveda, J. Studies of the influence of ambroxol and dexamethasone on maturation of surfactant system in lungs of albino mice. Prog Respir Res 1981; 15: 256–64.
Luerti, M., Casolati, E., Rossi, G., Zavattini, G. and Corbella, E. Alternatives to steroids for prevention of RDS. In: Vignali, M., Cosmi, E. V. and Luerti, M., eds. Diagnosis and Treatment of Fetal Lung Immaturity, Milan. Masson, 1986; 116–26.
Lowenberg, E., Jiminez, L., Martinez, M. and Pommier, M. Effects of ambroxol on biochemical fetal lung maturity and prevention of the respiratory distress syndrome. Prog Resp Res 1981; 15: 240–6.
Carrera, G., Liberatore, A., Pirelli, A. and Riboni, G. Intravenous ambroxol administration and IRDS in preterm infants (Abstr.) Biol Neonate 1985; 48: 367.
Wauer, R. R., Schmalisch, G., Menzel, K., Schroder, M., Muller K., Tiller, R. et al. The antenatal use of ambroxol (bromhexine metabolite VIII) to prevent hyaline membrane disease: a controlled double-blind study. Biol Res Preg 1982; 3: 84–91.
Lorenz, U., Ruttger, S. H., Fux, G. and Kubli, K. Fetal pulmonary surfactant induction by bromhexine metabolite VIII. Am J Obstet Gynecol 1974; 119: 1126–8.
Lowenberg, E., Escobedo, F. and Jiminez, L. Prevention of RDS with ambroxol. In: Cosmi, E. V. and Scarpelli, E. M., eds. Pulmonary Surfactant System, Amsterdam. Elsevier, 1983; 173–8.
Editor information
Editors and Affiliations
Copyright information
© 1991 Macmillan Publishers Limited
About this chapter
Cite this chapter
Scarcella, A., Stanzione, M., Zullo, F., Rota, G., Ciccimarra, F. (1991). Prevention of HMD and survival in low-birth-weight infants. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_14
Download citation
DOI: https://doi.org/10.1007/978-1-349-12553-1_14
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-12555-5
Online ISBN: 978-1-349-12553-1
eBook Packages: EngineeringEngineering (R0)