Skip to main content
SpringerLink
Log in
Book cover

The Surfactant System of the Lung pp 1–6Cite as

Gene structure of the pulmonary surfactant proteins SP-A, SP-B and SP-C

  • Chapter

  • 16 Accesses

Abstract

The application of molecular biology to the study of pulmonary surfactant has resulted in the isolation and characterization of the genes encoding surfactant proteins SP-A, SP-B and SP-C. Nucleotide sequences of the genes provide a precise amino acid sequence of the polypeptides and a starting point for the elucidation of the genetic elements, acting in cis, which may control lung-specific, developmental and hormonal control of surfactant protein synthesis. The present summary will provide an overview of recent progress made in the analysis of the surfactant protein genes, primarily describing work from our laboratory.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. White, R. T., Damm, D., Miller, J., Spratt, K., Schilling, J., Hawgood, S., Benson, B. and Cordell, B. Isolation and characterization of the human pulmonary surfactant apoprotein gene. Nature 1985; 317: 361–3.

    Article  Google Scholar 

  2. Korfhagen, T. R.,Glasser, S. W., Bruno, M. D., Clark, J. C., Pilot-Matias T. J. and Whitsett, J. A. Complexity of human pulmonary SP-A gene sequences. Pediatr Res 1988; 23: 513A (Abstr).

    Article  Google Scholar 

  3. Hawgood, S. Pulmonary surfactant apoproteins: a review of protein and genomic structure. Am J Physiol: Lung, Cell Mol Physiol 1989; 1: 13–22.

    Google Scholar 

  4. Whitsett, J. A. and Weaver, T. E. Pulmonary surfactant proteins: implications for surfactant replacement therapy. In: Shapiro, D. L. and Notter, R. H. eds. Surfactant Replacement Therapy, New York: Alan R. Liss, 1989; 71–89.

    Google Scholar 

  5. Pilot-Matias, T. J., Kister, S. E., Fox, J. L., Kropp, K., Glasser, S. W. and Whitsett, J. A. Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B. DNA 1989; 8: 75–86.

    Article  Google Scholar 

  6. Whitsett, J. A., Weaver, T. E., Clark, J. C., Sawtell, N., Glasser, S. W., Korfhagen, T. R. and Hull, W. M. Glucocorticoid enhances surfactant proteolipid Phe and pVal synthesis and RNA in fetal lung. J Biol Chem 1987; 262: 15618–23.

    Google Scholar 

  7. Glasser, S. W., Korfhagen, T. R., Perme, C. M., Pilot-Matias, T. J., Kister, S. E and Whitsett, J. A. Two genes encoding human pulmonary surfactant proteolipid SP-C. J Biol Chem 1988; 263: 10326–31.

    Google Scholar 

Download references

Authors
  1. Jeffrey A. Whitsett
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Second Institute of Gynaecology and Obstetrics, University of La Sapienza, Rome, Italy

    E. V. Cosmi

  2. Institute of Gynaecology and Obstetrics, University of Perugia, Policlinico Monteluce, Perugia, Italy

    G. C. Di Renzo

  3. Second Institute of Gynaecology and Obstetrics, University of La Sapienza, Rome, Italy

    M. M. Anceschi

Copyright information

© 1991 Macmillan Publishers Limited

About this chapter

Cite this chapter

Whitsett, J.A. (1991). Gene structure of the pulmonary surfactant proteins SP-A, SP-B and SP-C. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-12553-1_1

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-12555-5

  • Online ISBN: 978-1-349-12553-1

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation