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Molecular Basis of Neocarzinostatin Action: Roles of DNA Microstructure and Thiol in the Mechanism of Bistranded Oxidative Damage

  • Chapter
Molecular Aspects of Anticancer Drug-DNA Interactions

Part of the book series: Topics in Molecular and Structural Biology ((TMSB))

Abstract

Antitumour antibiotics that interact with DNA appear to do so by seeking out specific structures and/or functional groups on the DNA. This was first shown for actinomycin D (Goldberg and Rabinowitz, 1962; Goldberg et al. 1962) and then for other agents (Ward et al. 1965; Goldberg and Friedman, 1971) that formed either physical or covalent complexes with DNA. Several of these agents demonstrate a sequence preference in their interaction with DNA (see Pullman and Jortner, 1990), and the structure of the complex formed is generally of a single type, such as that resulting from the alkylation of the N3 of adenine by the drug CC-1065 (Hurley et al. 1988), lying in the DNA minor groove.

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Authors
  1. Irving H. Goldberg
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Editors and Affiliations

  1. Institute of Cancer Research, Sutton, Surrey, UK

    Stephen Neidle

  2. Department of Pharmacology, University of Cambridge, CB2 1QJ, Cambridge, UK

    Michael J. Waring

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Goldberg, I.H. (1993). Molecular Basis of Neocarzinostatin Action: Roles of DNA Microstructure and Thiol in the Mechanism of Bistranded Oxidative Damage. In: Neidle, S., Waring, M.J. (eds) Molecular Aspects of Anticancer Drug-DNA Interactions. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-12356-8_8

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  • DOI: https://doi.org/10.1007/978-1-349-12356-8_8

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