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Design of Sequence-specific Agents: Lexitropsins

  • Chapter
Molecular Aspects of Anticancer Drug-DNA Interactions

Part of the book series: Topics in Molecular and Structural Biology ((TMSB))

Abstract

The guiding principle behind efforts to develop DNA sequence-specific agents is that greater biological response may be achieved for a given dose compared with a sequence-neutral agent, thereby reducing toxic side-effects. A related goal is the selective suppression of transcription from particular gene sequences (Stephenson and Zamecnik, 1978; Izant and Weintraub, 1984).

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Authors
  1. J. William Lown
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Editor information

Editors and Affiliations

  1. Institute of Cancer Research, Sutton, Surrey, UK

    Stephen Neidle

  2. Department of Pharmacology, University of Cambridge, CB2 1QJ, Cambridge, UK

    Michael J. Waring

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Lown, J.W. (1993). Design of Sequence-specific Agents: Lexitropsins. In: Neidle, S., Waring, M.J. (eds) Molecular Aspects of Anticancer Drug-DNA Interactions. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-12356-8_11

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  • DOI: https://doi.org/10.1007/978-1-349-12356-8_11

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-12358-2

  • Online ISBN: 978-1-349-12356-8

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