Abstract
Experimental allergic encephalomyelitis (EAE) has been studied as experimental model for human primary demyelinating diseases such as multiple sclerosis. There are a number of experimental data indicating altered function of the blood-brain barrier (BBB) during the acute and chronic-relapsing forms of EAE (Bradbury, 1989).
This is a preview of subscription content, log in via an institution.
References
Bradbury, M. W. (1989). Transport across the blood-brain barrier. In Neuwelt, E. A. (Ed.), Implication of the Blood-Brain Barrier and its Manipulation, Vol. 1, Plenum, New York, pp. 119–137
Colover, J., Skundrić, D. S. and Zloković, B. (1989). Chain of events leading to demyelination. In Gonsette, R. E. and Delmotte, P. (Eds), Recent Advances in Multiple Sclerosis Therapy. Elsevier Science Publishers, B.V., pp. 305–308
Daniel, P. M., Lam, D. K. C. and Pratt, O. E. (1981). Changes in the effectiveness of the blood-brain and blood-spinal cord barrier in experimental allergic encephalomyelitis. J. Neurol. Sci., 52, 211–219
Skundrić, D. S., Zloković, B. V., Colover, J., Dumonde, D. and Rakić, Lj. (1990). Transport of homologous immunoglobulin G across the blood-brain barrier during EAE in the guinea-pig. Period. Biol., 92, 1
Zloković, B. V., Begley, D. J., Djurić, B. and Mitrović, D. M. (1986). Measurements of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-α-amino-isobutyric acid, J. Neurochem., 46, 1444–1459
Zloković, B. V., Skundrić, D. S., Segal, M. B., Colover, J., Jankov, R. M., Pejnović, N., Lacković, V., Mackić, J., Lipovac, M., Davson, H., Kasp, E., Dumonde, D. and Rakić, Lj. (1989). Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea-pig. Metab. Brain Dis., 4(1), 33–40
Editor information
Editors and Affiliations
Copyright information
© 1992 The Editor and Contributors
About this chapter
Cite this chapter
Skundrić, D.S., Zloković, B.V., Segal, M.B., Rakić, L.J., Davson, H. (1992). Role of the Blood—Brain Barrier in Immunopathogenesis of Experimentally Induced Autoimmune Demyelination. In: Segal, M.B. (eds) Barriers and Fluids of the Eye and Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-12306-3_20
Download citation
DOI: https://doi.org/10.1007/978-1-349-12306-3_20
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-12308-7
Online ISBN: 978-1-349-12306-3
eBook Packages: EngineeringEngineering (R0)