Abstract
We applied the brain vascular perfusion method to determine the kinetics of entry to inert polar molecular D-[3H]-mannitol into the parietal cortex, hippocampus and caudate nucleus in guinea-pigs with sensorimotor (SM) and occipital (Oc) cortical lesions. In the control group of animals, with Oc lesions, only a moderate increase of blood-brain (BBB) permeability to D-mannitol was found after the ipsilateral lesion and no permeability changes occurred after the contralateral lesion, which was expressed by graphically determined unidirectional transfer constant, Kin. In a separate series of experiments, in the guinea-pigs with SM cortical lesions, estimated Kin values indicated a marked increase of blood-to-brain transport of D-[3H)-mannitol in all brain regions studied, the changes being significantly higher after the contralateral lesion. Amphetamine pretreatment in the guinea-pigs with SM and Oc cortical lesions induced more pronounced BBB permeability changes for D-[3H]-mannitol in all brain areas studied.
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References
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Rakić, L.M. et al. (1992). Opening of the Blood—Brain Barrier to D-Mannitol Induced by Sensorimotor Cortical Lesions in the Anaesthetized Guinea-pig. In: Segal, M.B. (eds) Barriers and Fluids of the Eye and Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-12306-3_14
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DOI: https://doi.org/10.1007/978-1-349-12306-3_14
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-12308-7
Online ISBN: 978-1-349-12306-3
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