Receptors Linked to Hydrolysis of Choline Phospholipids: the Role of Phospholipase D in a Putative Mechanism of Signal Transduction

  • Konrad Löffelholz


The structure and basic functions of biomembranes are essentially determined by the lipid bilayer. In contrast, specific membrane functions, such as signal recognition and transduction and transport processes, have been preferentially attributed to proteins that are embedded in the outer or inner leaflet of this bilayer or may span the membrane up to five times or more, as in the case of receptor molecules. The segregating view of membrane protein and lipid functions may have delayed a broad research interest in the dynamic interactions between these components of the membrane. The present review is devoted to such a recently discovered interaction: the coupling of receptor activation and hydrolysis of Ch-containing glycerophospholipids, the major constituents of the lipid bilayer in mammals.


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Copyright information

© Macmillan Publishers Limited 1990

Authors and Affiliations

  • Konrad Löffelholz
    • 1
  1. 1.Department of PharmacologyUniversity of MainzMainzFederal Republic of Germany

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