Radioimmunotherapy with 90Yttrium—Anti-Idiotype Monoclonal Antibody

  • Barbara A. Parker
  • Samuel E. Halpern
  • Ivor Royston

Abstract

B cell lymphoma, a monoclonal proliferation of B cells derived from a single transformed cell, expresses surface immunoglobulin (Ig) containing a unique variable (V) region (Fialkow et al., 1973; Levy et al., 1977). Variable region antigenic epitopes that are unique to the Ig molecule are termed private idiotypes (Ids), whereas antigenic epitopes that may be shared among Ig molecules are termed cross-reactive, or shared, Ids. These surface Ig Ids can serve as lymphoma tumor markers and can be chosen to be either tumor-specific in the case of a private Id or tumor-associated in the case of a shared Id.

Keywords

Toxicity Lymphoma Iodine Shrinkage Oncol 

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References

  1. Basham, T. Y., Kaminski, M. S., Kitamura, K., Levy, R., and Merigan, T. C. (1986). J. Immunol 137, 3019–3024.PubMedGoogle Scholar
  2. Brown, S. L., Dilley, J., Levy, R. (1980) J. Immunol. 125, 1037–1043.PubMedGoogle Scholar
  3. Brown, S. L., Miller, R. A., Horning, S. J., Czcerwinski, D., Hart, S. M., McElderry, R., Basham, T., Warnke, R., Merigan, T. C., and Levy, R. (1989) Blood 73, 651–661.PubMedGoogle Scholar
  4. Carroll, W. L., Thielemans, K., Dilley, J., Levy, R. (1986) J. Immunol. Methods 89, 61–72.PubMedCrossRefGoogle Scholar
  5. Cleary, M. L., Meeker, T. C., Levy, S., Lee, E., Trela, M., Sklar, J., and Levy, R. (1986) Cell 44, 97–106.PubMedCrossRefGoogle Scholar
  6. Denardo, S. J., Denardo, G. L., O’Grady, L. F., Levy, N. B., Mills, S. L., Macey, J., McGahan, J. R., Miller, C. H., and Epstein, A. L. (1988) Antibody, Immunoconjugates, and Radiopharmaceuticals 1, 17–33.Google Scholar
  7. Evans, T. L., and Miller, R. A. (1988) Biotechniques 6, 762–767.PubMedGoogle Scholar
  8. Fialkow, P. J., Klein, E., Klein, G., and Sigh, S. (1973) J. Exp. Med. 138, 89–102.PubMedCentralPubMedCrossRefGoogle Scholar
  9. Halpern, S. E., and Dillman, R. O. (1987) J. Biol. Response Mod. 6, 235–262.PubMedGoogle Scholar
  10. Halpern, S. E., Stern, R. J., Hagan, P. L., Chen, A., Frincke, J., Bartholomew, R. M., David, G., and Adams, T. (1983) in Radioimmunoimaging and Radioimmunotherapy (Burchiel, S., and Rhodes, B., eds.), pp. 198–205, Elsevier North-Holland, New York.Google Scholar
  11. Leichner, P. K., Yang, N., Frenkel, T. L., Loudenslager, D. M., Hawkins, W. G., Klein, J. L., and Order, S. E. (1988) Int. J. Radiat. Oncol. Biol. Phys. 14, 1033–1042.PubMedCrossRefGoogle Scholar
  12. Levy, R., and Dilley, J. (1978) Proc. Natl Acad. Sci. USA 75, 2411–2415.PubMedCentralPubMedCrossRefGoogle Scholar
  13. Levy, R., Warnke, R., Dorfman, R. F., and Haimovich, J. (1977) J. Exp. Med. 145, 1014–1028.PubMedCrossRefGoogle Scholar
  14. Meeker, T. C., Lowder, J., Cleary, M. L., Stewart, S., Warnke, R., Sklar, J., and Levy, R. (1985a) N. Engl. J. Med. 312, 1658–1665.PubMedCrossRefGoogle Scholar
  15. Meeker, T. C., Lowder, J., Maloney, D. G., Miller, R. A., Thielemans, K., Warnke, R., Sklar, J., and Levy, R. (1985b) Blood 65, 1349–1363.PubMedGoogle Scholar
  16. Miller, R. A., Hart, S., Samoszuk, M., Coulter, C., Brown, S., Czerwinski, D., Kelkenberg, J., Royston, I., and Levy, R. (1989) N. Engl. J. Med. 321, 851–858.PubMedCrossRefGoogle Scholar
  17. Miller, R. A., Maloney, D. G., Warnke, R., and Levy, R. (1982) N. Engl. J. Med. 306, 517–522.PubMedCrossRefGoogle Scholar
  18. National Cancer Institute Sponsored Study of Classifications of Non-Hodgkin’s Lymphomas (1982) Cancer 49, 2112–2135.CrossRefGoogle Scholar
  19. Order, S. E., Stillwagon, G. B., Klein, J. L., Leichner, P. K., Siegelman, S. S., Fishman, E. K., Ettinger, D. S., Haulk, T., Kopher, K., and Finney, K. (1985) J. Clin. Oncol. 3(12), 1573–1582.PubMedGoogle Scholar
  20. Order, S. E., Vriesendorp, H. M., Klein, J. L., and Leichner, P. K. (1988) Antibody, Immunocong., and Radiopharmaceuticals 1, 163–168.Google Scholar
  21. Parker, B. A., Vassos, A. B., Halpern, S. E., Miller, R. A., Hupf, H., Amox, D. G., Simoni, J. L., Starr, R. J., Green, M. R., and Royston, I. (1990) Cancer Res., in press.Google Scholar
  22. Press, O. W., Eary, J. E., Badger, C. C., Martin, P. J., Appelbaum, F. R., Levy, R., Miller, R., Brown, S., Nelp, W. B., Krolin, K. A., Fisher, D., DiSantes, K., Porter, B., Kidd, P., Thomas, E. D., and Bernstein, I. D. (1989) J. Clin. Oncol. 7, 1027–1038.Google Scholar
  23. Rosen, S. T., Zimmer, A. M., Goldman-Leikin, R., Gordon, L. I., Kazikiewicz, J. M., Kaplan, E. H., Variakojis, D., Marder, R. J., Dykewicz, M. S., Piergiess, A., Silverstain, E. A., Roenigk, H. H., Jr., and Spies, S. M. (1987) J. Clin. Oncol. 5, 562–573.PubMedGoogle Scholar
  24. Schroff, R. W., Foon, K. A., Beatty, S. M., Oldham, R. K., Morgan, A. C. (1985) Cancer Res. 45, 879–885.PubMedGoogle Scholar
  25. Shawler, D. L., Bartholomew, R. M., Smith, L. M., and Dillman, R. O. (1985) J. Immunol. 135, 1530–1535.PubMedGoogle Scholar
  26. Thielemans, K., Maloney, D. G., Meeker, T., Fujimoto, J., Doss, C., Warnke, R., Bindl, J., Gralow, J., Miller, R. A., and Levy, R. (1984) J. Immunol. 133, 495–501.PubMedGoogle Scholar
  27. Vriesendorp, H. M., Herpst, J. M., Leichner, P. K., Klein, J. L., and Order, S. E. (1989) Int. J. Radiat. Oncol. Biol. Phys. 17, 815–821.PubMedCrossRefGoogle Scholar

Copyright information

© Stockton Press 1990

Authors and Affiliations

  • Barbara A. Parker
  • Samuel E. Halpern
  • Ivor Royston

There are no affiliations available

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