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Therapeutic Monoclonal Antibodies pp 75–94Cite as

Palgrave Macmillan

Gangliosides as Targets for Monoclonal Antibody Therapy of Cancer

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Abstract

Certain classes of antibodies are capable of lysing tumor cells by either activating complement (complement-dependent cytotoxicity, or CDC) or by mediating immune effector cells (antibody-dependent cellular cytotoxicity, or ADCC). Non-cytotoxic antibodies are also capable of cell lysis after coupling with toxins, chemotherapeutic drugs, or radioisotopes. In addition, there are antibodies capable of blocking cell surface receptors, thereby inhibiting growth, metastasis, and invasion of the tumor cells. In view of these anti-tumor capabilities, a number of clinical trials involving monoclonal antibodies (Mab) targeted against human cancer have been performed. With the technical feasibility to produce large quantities of purified monoclonal antibodies with defined specificity, isotype, and function, monoclonal antibodies have generated much hope for the immunotherapy of human cancer.

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Authors
  1. Reiko F. Irie
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  2. Mepur H. Ravindranath
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Carl A. K. Borrebaeck James W. Larrick

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© 1990 Stockton Press

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Irie, R.F., Ravindranath, M.H. (1990). Gangliosides as Targets for Monoclonal Antibody Therapy of Cancer. In: Borrebaeck, C.A.K., Larrick, J.W. (eds) Therapeutic Monoclonal Antibodies. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-11894-6_5

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