5-HT has been implicated in the mechanisms of anxiety since the seminal studies of Graeff and Schoenfeld (1970) and Geller and Blum (1970). They showed that 5-HT receptor antagonists and inhibition of 5-HT synthesis prevented the ability of foot shock to suppress operant behaviour. The subsequent observation that the anxiolytic benzodiazepine oxazepam decreased 5-HT turnover lead to the suggestion that anxiolytic drugs work by inhibition of 5-HT function (Wise et al., 1972).
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