Skip to main content
SpringerLink
Log in
Book cover

New Concepts in Anxiety pp 313–319Cite as

Cholecystokinjn Tetrapeptide: a Provocation Agent for Research in Panic Disorder?

  • Chapter

Abstract

Panic disorder represents a significant psychiatric illness in the general population and is associated with a number of distressing and disabling complications (Marks, 1987). The core symptom of panic disorder is the repeated occurrence of panic attacks. These attacks are characterized by discrete episodes of intense anxiety or fear accompanied by somatic, cognitive and behavioural symptoms. When panic disorder is associated with extensive phobic avoidance and impairment of overall functioning a diagnosis of panic disorder with agoraphobia is made.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Beinfeld, M. C. (1988). Cholecystokinin and gastrin chemistry, distribution, release, and activity. In Negro-Vilan, A. and Conn, P. M. (eds.), Peptide Hormones: Effects and Mechanisms of Action, vol. II, CRC Press, Boca Raton, Ha, 41–77.

    Google Scholar 

  • Bradwejn, J. and de Montigny, C. (1984). Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurons. Nature, 312, 363–4.

    Article  PubMed  CAS  Google Scholar 

  • Bradwejn, J., Koszycki, D. and Meterissian, G. (1990). Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder. Can. J. Psychiatry, 35, 83–5.

    PubMed  CAS  Google Scholar 

  • Bradwejn, J., Koszycki, D., Meterissian, G. and Shriqui, C. (1989). Cholecystokinin panic: patient control differences. New Research Program and Abstracts, 142nd Meeting of American Psychiatric Association, San Francisco, NR 334, p. 183.

    Google Scholar 

  • Braestrup, C. and Squires, R. F. (1978). Pharmacological characterization of benzodiazepine receptors in the brain. Eur. J. Pharmacol., 48, 263–70.

    Article  PubMed  CAS  Google Scholar 

  • Charney, D. S., Woods, S. W., Goodman, W. K., Rifkin, B., Kinch, M., Aiken, B., Quadrino, L. and Heninger, G. (1986). Drug treatment of panic disorder: The comparative efficacy of imipramine, alprazolam, and trazodone. J. Clin. Psychiatry, 47, 580–6.

    PubMed  CAS  Google Scholar 

  • Crowe, R. R., Noyes, R., Pauls, D. L. and Slyman, D. J. (1983). A family study of panic disorder. Arch. Gen. Psychiatry, 40, 1065–9.

    Article  PubMed  CAS  Google Scholar 

  • de Montigny, C. (1989). Cholecystokinin-tetrapeptide induces panic-like attacks in healthy volunteers. Arch. Gen. Psychiatry, 46, 511–7.

    Article  PubMed  Google Scholar 

  • Gorman, J. M., Liebowitz, M. R., Fyer, A. J. and Stein, J. (1989). Neuroanatomical hypothesis for panic disorder. Am. J. Psychiatry, 146, 148–61.

    Article  PubMed  CAS  Google Scholar 

  • Gorman, J. M., Fyer, M. R., Liebowitz, M. R. and Klein, D. F. (1987). In Meltzer, H. Y. (ed.), Psychopharmacology: The Third Generation of Progress, Raven, New York, 985–93.

    Google Scholar 

  • Guttmacher, L. B., Murphy, D. L. and Insel, T. R. (1983). Pharmacologic models of anxiety. Compr. Psychiatry, 24, 312–26.

    Article  PubMed  CAS  Google Scholar 

  • Karkanias, C. D., Block, G. A., Reines, S. and Bradwejn, J. (1989). Neurobiology of panic disorder. Letter, Am. J. Psychiatry, 146, 1357.

    CAS  Google Scholar 

  • Kubota, K., Sugaya, K., Kunagne, N. and Matsuda, I. (1985). Cholecystokinin antagonism by benzodiazepines in the contractile response of the isolated guinea pig gallbladder. Eur. J. Pharmacol., 110, 225–31.

    Article  PubMed  CAS  Google Scholar 

  • Liebowitz, M. R., Fyer, A. J., Gorman, J. M., Campeas, R., Levin, A., Davies, S. R., Goetz, D. and Klein, D. F. (1986). Alprazolam in the treatment of panic disorder. J. Clin. Psychopharm., 6, 13–20.

    Article  CAS  Google Scholar 

  • Marks, I. M. (1987). Behavioural aspects of panic disorder. Am. J. Psychiatry, 144, 1160–5.

    Article  PubMed  CAS  Google Scholar 

  • Mohler, H., Okada, T., Heiz, P. and Ulrich, J. (1978). Biochemical identification of the site of action of benzodiazepines in human brain by H3-diazepam binding. Life Sci., 22, 985–96.

    Article  PubMed  CAS  Google Scholar 

  • Redmond, D. E. Jr (1987). Studies of the nucleus locus coeruleus in monkeys and hypothesis for neuropsychopharmacology. In Meltzer, H. Y. (ed.), Psychopharmacology: The Third Generation of Progress, Raven, New York.

    Google Scholar 

  • Wittchen, H. U. (1988). In Panic and Phobias 2, Hand, I. and Wittchen, H. U. (eds.), Springer, Berlin, 3–17.

    Chapter  Google Scholar 

  • Vanderhaeghen, J. J. and Crawley, J. N. (1985). Neuronal cholecystokinin. Ann. NY Acad Sci., 448, 198–219.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychopharmacology, St Mary’s Hospital Center, 3830 Lacombe Avenue, Montréal, Quebec, H3T 1M5, Canada

    J. Bradwejn

Authors
  1. J. Bradwejn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Koszycki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Payeur
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pierre Fabre Médicament, Castres, France

    M. Briley

  2. Psychopharmacology Research Unit, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    S. E. File

Copyright information

© 1991 Macmillan Publishers Limited

About this chapter

Cite this chapter

Bradwejn, J., Koszycki, D., Payeur, R. (1991). Cholecystokinjn Tetrapeptide: a Provocation Agent for Research in Panic Disorder?. In: Briley, M., File, S.E. (eds) New Concepts in Anxiety. Palgrave, London. https://doi.org/10.1007/978-1-349-11847-2_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-11847-2_23

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-11849-6

  • Online ISBN: 978-1-349-11847-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation