Abstract
Mounting evidence indicates important roles for nerve growth factor (NGF) in the developing and mature central nervous system where cholinergic systems appear to be a prime target for NGF (see Dreyfus, 1989a; Ebendal, 1989; Persson et al., this volume; Thoenen et al., 1987; Whittemore and Seiger, 1987). While the sensitivity to NGF might differ during development and between different transferase (ChAT) and NGF receptor (NGF-R) immunoreactivity in both rodents and primates including man (Batchelor et al., 1989; Dawbarn, 1988; Hefti and Mash, 1989; Kordower et al., 1988, 1989; Mesulam et al., 1989; Mufson et al., 1989; Woolf et al., 1989). However, both during development and in the adult nervous system, NGF-R has a more widespread distribution than the cholinergic systems, being prominent, e.g. also in cerebellum and several other areas (Buck et al., 1988; Ernfors et al., 1988), suggesting that also non-cholinergic systems might be NGF-sensitive. Indeed, there are reports of colocalization of NGF-R and GABA uptake (Arimatsu and Miyamoto, 1989; Dreyfus et al., 1989b). Of particular interest is the fact that the major cholinergic projection systems from septum to hippocampus and from basal forebrain to cortex cerebri depend on NGF produced by the target areas. Thus, when the septo-hippocampal pathway is lesioned, the axotomized cholinergic neurons can be rescued by injection of exogenous NGF (Kromer, 1987; Williams et al., 1986). There is a loss of cholinergic neurons in the forebrain during normal aging (Bartus et al., 1982) and in senile dementia of Alzheimer’s type, this loss is markedly accelerated (Whitehouse et al., 1982). However, remaining cholinergic neurons in Alzheimer’s disease appear to have sufficient levels of NGF-R mRNA and NGF-R (Goedert et al., 1989; Kordower et al., 1989), suggesting that these neurons continue to be NGF-sensitive and therefore that NGF might be beneficial in the senile dementias.
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Olson, L. et al. (1990). Strategies to Increase NGF Levels and Effects thereof on Lesioned and Grafted Brain Tissue. In: Björklund, A., Aguayo, A.J., Ottoson, D. (eds) Brain Repair. Wenner-Gren Center International Symposium Series. Palgrave, London. https://doi.org/10.1007/978-1-349-11358-3_7
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DOI: https://doi.org/10.1007/978-1-349-11358-3_7
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