Abstract
The development of the nervous system is punctuated by periods of natural cell death. Neurogenesis produces about twice the adult number of neurons, resulting in an overpopulation that is later pruned by selective neuronal death (Cowan et al., 1984). The magnitude of this natural cell death is modulated by interactions with other cells. For example, neurons typically must contact targets to survive. It is widely accepted that target tissues produce a class of survival-promoting proteins known as neurotrophic factors for which neurons must compete.
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Johnson, E.M., Koike, T., Juhasz, A., Martin, D.P. (1990). Trophic Factor Deprivation Causes Neuronal Death via an Active Process Modulated by Intracellular Calcium. In: Björklund, A., Aguayo, A.J., Ottoson, D. (eds) Brain Repair. Wenner-Gren Center International Symposium Series. Palgrave, London. https://doi.org/10.1007/978-1-349-11358-3_3
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DOI: https://doi.org/10.1007/978-1-349-11358-3_3
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