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Functional Analysis of Neural Grafts in the Neostriatum

  • Chapter
Brain Repair

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

Abstract

In contrast to an earlier pessimism, contemporary brain research appears to offer new hope for neural repair after CNS injury. It is now recognised that synaptic and regenerative plasticity may represent normal processes in the mammalian CNS that permit a limited degree of spontaneous repair and recovery in the damaged brain. This has led to several strategies to promote neural repair. Firstly, the identification and isolation of neurotrophic factors that stimulate and guide axonal growth in development and that maintain neurones in maturity has led to their application to inhibit selective cell death and to promote regrowth of traumatized systems in the brain. Nevertheless, once cells do die, neurogenesis does not take place in the adult mammalian brain. Consequently, a second strategy has been the development of neural transplantation techniques for surgical replacement of lost populations of neurones within the brain.

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Authors
  1. Stephen B. Dunnett
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Editors and Affiliations

  1. Department of Medical Cell Research, University of Lund, Sweden

    Anders Björklund

  2. Center for Research in Neuroscience, Montreal General Hospital, Canada

    Albert J. Aguayo

  3. Wenner-Gren Center Foundation, Stockholm, Sweden

    David Ottoson

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© 1990 The contributors

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Dunnett, S.B. (1990). Functional Analysis of Neural Grafts in the Neostriatum. In: Björklund, A., Aguayo, A.J., Ottoson, D. (eds) Brain Repair. Wenner-Gren Center International Symposium Series. Palgrave, London. https://doi.org/10.1007/978-1-349-11358-3_26

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  • DOI: https://doi.org/10.1007/978-1-349-11358-3_26

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-11360-6

  • Online ISBN: 978-1-349-11358-3

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