Laminin Receptors: From PC12 Cells to PNS
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The spatial and functional organization of individual cells into tissues is an event at the heart of metazoan development. This organization attains extraordinary complexity in the nervous system where inputs and outputs are matched at the level of single neurons. For example, in the visual system of frogs the axons of retinal ganglion cells form an array of synaptic connections in the tectum that reflects, with elegant precision, the positions of their somata in the retina. This topographic projection of the retina onto the tectum led Sperry (1963) to propose the now-famous chemoaffinity hypothesis.
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