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Development and Long-term Survival of Brain Neurons in Culture: Role of Astroglia-Derived Neurotrophic and Neurite-promoting Factors, Neuronal Cell/Contact Density and Bioelectrical Activity

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Book cover Brain Repair

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

Astrocytes are traditionally regarded as having functions in neuronal guidance during development of the central nervous system (CNS), exchange of nutritional and metabolic substances with neurons, clearance or maintenance of neurotransmitter and ion concentrations in synaptic regions and phagocytosis of debris resulting from cell death during development, disease or after injury (for reviews Stewart and Rosenberg, 1979; Varon and Somjen, 1979). In recent years the ability of central glia, to express additional functions within the CNS has been suspected. These functions relate to (a) trophic support for the survival and functional maintenance of CNS neurons and (b) stimulation of neurite growth.

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Authors
  1. Hans W. Müller
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Editor information

Editors and Affiliations

  1. Department of Medical Cell Research, University of Lund, Sweden

    Anders Björklund

  2. Center for Research in Neuroscience, Montreal General Hospital, Canada

    Albert J. Aguayo

  3. Wenner-Gren Center Foundation, Stockholm, Sweden

    David Ottoson

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© 1990 The contributors

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Müller, H.W. (1990). Development and Long-term Survival of Brain Neurons in Culture: Role of Astroglia-Derived Neurotrophic and Neurite-promoting Factors, Neuronal Cell/Contact Density and Bioelectrical Activity. In: Björklund, A., Aguayo, A.J., Ottoson, D. (eds) Brain Repair. Wenner-Gren Center International Symposium Series. Palgrave, London. https://doi.org/10.1007/978-1-349-11358-3_13

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  • DOI: https://doi.org/10.1007/978-1-349-11358-3_13

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-11360-6

  • Online ISBN: 978-1-349-11358-3

  • eBook Packages: EngineeringEngineering (R0)

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