Skip to main content
SpringerLink
Log in

Atrial Natriuretic Factors and the Central Nervous System: Receptors and Functions

  • Chapter
Current Aspects of the Neurosciences

Abstract

Mammalian atrial cardiocytes contain storage granules which morphologically resemble those found in other cells producing peptide hormones. These granules have been shown to contain a natriuretic and diuretic factor (De Bold, 1982; Garcia et al, 1982). This factor is the 126 arnino acid atrial natriuretic factor (ANF) propeptide, which, in its mature form, is a 28 amino acid circulating peptide in both rat and human (Cantin and Genest, 1985; De Bold, 1985; Anderson and Bloom, 1986; Atlas, 1987). This active peptide hormone has potent biological effects on the peripheral vascular tone, and on the regulation of fluid and electrolyte balance (Cantin and Genest, 1985; De Bold, 1985; Anderson and Bloom, 1986; Atlas, 1987; Goetz, 1988). Many of the established actions of ANF have been first described using crude atrial extracts or partially purified preparations. These effects have now been confirmed using pure synthetic peptides. In addition to natriuresis, diuresis and vasorelaxation, ANF-like peptides induce a variety of biological effects in different target tissues. For example, they modulate aldosterone production as well as vasopressin and androgen release (Bex and Corbin, 1985; Cantin and Genest, 1985; De Bold, 1985; Anderson and Bloom, 1986; Pandey et al., 1986; Mukhopadhyay et al, 1986; Atlas, 1987; Goetz, 1988). It is now clear that ANF actions are mediated by highly selective and specific ANF receptor sites localized on plasma membranes as well as inside the cells of target tissues (De Lean et al, 1984; Napier et al, 1984; Morel and Heisler, 1988).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

  • Abou-Samra, A.-B., Catt, K. J. and Aguilera, G. (1987). Synthetic atrial natriuretic factors (ANFs) stimulate guanosine 3′,5′-monophosphate production but not hormone release in rat pituitary cells: peptide contamination with a gonadotfophin-releasing hormone agonist explains luteinizing hormone-releasing activity of certain ANFs. Endocrinology, 120, 18–24

    Google Scholar 

  • Anderson, J. V. and Bloom, S. R. (1986). Atrial natriuretic peptide: what is the excitement all about?J. Endocr., 110, 7–17

    Google Scholar 

  • Antunes-Rodrigues, J., McCann, S. M., Rogers, L. C. and Samson, W. K. (1985a). Atrial natriuretic factor inhibits dehydration- and angiotensin II-induced water intake in the conscious, unrestrained rat. Proc. Natl Acad. Sci. USA, 82, 8720–8723

    Google Scholar 

  • Antunes-Rodrigues, J., McCann, S. M. and Samson, W. K. (1985b). Central administration of atrial natriuretic factor inhibits saline preference in the rat. Endocrinology, 118, 1726–1728

    Google Scholar 

  • Atlas, S. A. (1987). Atrial natriuretic factor: a new hormone of cardiac origin. In Recent Progress in Hormone Research, Vol. 42 (ed. R. O. Greep). Academic Press, New York, pp. 207–249

    Google Scholar 

  • Ballermann, B. J. and Brenner, B. N. (1986). Role of atrial peptides in body fluid homeostasis. Circ. Res., 58, 619–630

    Google Scholar 

  • Bex, F. and Corbin, A. (1985). Atrial natriuretic factor stimulates testosterone production by mouse interstitial cells. Eur. J. Pharmacol., 115, 125–126

    Google Scholar 

  • Bianchi, C, Anad-Srivastava, M. B., De Lean, A., Gutkowska, J., Forthomme, D., Genest, J. and Cantin, M. (1986a). Localization and characterization of specific receptors for atrial natriuretic factor in ciliary processes of the eye. Curr. Eye Res., 5, 283–293

    Google Scholar 

  • Bianchi, C, Gutkowska, J., Ballak, M. et al. (1986b). Radioautographic localization of 125 I-atrial natriuretic factor binding sites in the brain. Neuroendocrinology, 44, 365–372

    Google Scholar 

  • Bianchi, C, Gutkowska, J., Thibault, G., Garcia, R., Genest, J. and Cantin, M. (1985). Radioautographic localization of 125 I-atrial natriuretic factor (ANF) in rat tissues. Histoche-mistry, 82, 441–452

    Google Scholar 

  • Brunet, N., Gourdj, D., Tixier-Vidal, A., Pradelles, P., Morgat, J. L. and Fromageot, P. (1974). Chemical evidence for associated TRF with subcellular fractions after incubation of intact ra prolactin cells (GH3) with 3 H-labelled TRF. FEBS Lett., 38, 129–133

    Google Scholar 

  • Budzik, G. P., Firestone, S. L., Bush, B. N., Connolly, P. J., Rockway, T. W., Sarine, V. K. and Holleman, W. H. (1987). Divergence of ANF analogs in smooth muscle cGMP response and aorta vasorelaxation:evidence for receptor-subtypes. Biochem. Biophys. Res. Commun., 144, 422–431

    Google Scholar 

  • Cantin, M. and Genest, J. (1985). The heart and the atrial natriuretic factor. Endocr. Rev., 6, 107–127

    Google Scholar 

  • Cantin, M., Thibault, G., Garcia, R., Gutkowska, J., De Lean, A., Schiffrin, E., Seidah, N., Lazure, C. and Chretien, M. (1985). Structure-activity relationships of atrial natriuretic factors on renal function and renin release. Clin. Res., 33, 607 A

    Google Scholar 

  • Chabot, J.-G., Morel, G., Belles-Isles, M., Jeandel, L. and Heisler, S. (1988). Atrial natriuretic factor and exocrine pancreas: ultrastructural localization in acinar cells, Am. J. Physiol., 254, E301–E309

    Google Scholar 

  • Chabot, J.-G., Morel, G., Kopelman, M., Belles-Isles, M. and Heisler, S. (1987). Atrial natriuretic factor and exocrine pancreas: autoradiographic localization of binding sites and ultrastructural evidence for internalization of endogenous ANF. Pancreas, 4, 404–413

    Google Scholar 

  • Chabot, J.-G. and Quirion, R. (1989). Brain receptor sites for atrial natriuretic polypeptides. In Atrial Natriuretic Peptides (eds W. K. Samson and R. Quirion). CRC Press, Boca Raton (in press)

    Google Scholar 

  • Chabrier, P. E., Roubert, P. and Braquet, P. (1987). Specific binding of atrial natriuretic factor in brain microvessels. Proc. Nad. Acad. Sci. USA, 84, 2078–2081

    Google Scholar 

  • Chai, S. Y., Sexton, P. M., Allen, A. M., Fydor, R. and Mendelsohn, F. A. O. (1986). In vitro autoradiographic localization of ANF receptors in rat kidney and adrenal gland. Am. J. Physiol., 250, F153–F157

    Google Scholar 

  • Crabos, M., Ausiello, D. A., Haupert, G. T., Jr. and Cantiello, H. F. (1988). Atrial natriuretic peptide regulates release of Na+-K+-ATPase inhibitor from rat brain. Am. J. Physiol., 254, F912–F917

    Google Scholar 

  • Crandall, M. E. and Gregg, C. M. (1986). In vitro evidence for an inhibitory effect of atrial natriuretic peptide on vasopressin release. Neuroendocrinology, 44, 439–445

    Google Scholar 

  • Dalpé, M., Suranyi-Cadotte, B., Dennis, T. and Quirion, R. (1989). Atrial natriuretic peptide (ANF) and peripheral benzodiazepine receptors. Comparative distribution in brain and periphery. Peptides (in press)

    Google Scholar 

  • Debinski, W., Kuchel, O., Buu, N. T., Cantin, M. and Genest, J. (1987). Atrial natriuretic factor partially inhibits the stimulated catecholamine synthesis in superior cervical ganglia of rat. Neurosci. Lett.,77, 92–96

    Google Scholar 

  • De Bold, A. J. (1982). Tissue fractionation studies on the relationship between an atrial natriuretic factor and specific granules. Can. J. Physiol. Pharmacol., 60, 324–330

    Google Scholar 

  • De Bold, A. J. (1985). Atrial natriuretic factor: A hormone produced by the heart. Science, N.Y., 230,767–770

    Google Scholar 

  • De Lean, A., Gutkowska, J., McNicoll, N., Schiller, P. W., Cantin, M. and Genest, J. (1984). Characterization of specific receptors for atrial natriuretic factor in bovine adrenal zona glomerulosa. Life Sci., 35, 2311–2318

    Google Scholar 

  • De Léan, A., Ong, H., McNicoll, N., Racz, R., Gutkowska, J. and Cantin, M. (1985). Identification of aldosterone secretion inhibitory factor in bovine adrenal medulla. Life Sci., 36, 2375–2382

    Google Scholar 

  • Denef, C. (1986). Paracrine interactions in the anterior pituitary. Clin. Endocrinol. Metab., 15, 1–32

    Google Scholar 

  • De Vente, J., Bol, J. G. J. M., Hudson, L., Schipper, J. and Steinbusch, H. W. M. (1988). Atrial natriuretic factor-responding and cyclic guanosine monophosphate (cGMP)-producing cells in the rat hippocampus: a combined micropharmacological and immunocytochemical approach. Brain Res., 446, 387–395

    Google Scholar 

  • Doczi, T., Joo, F., Szerdahelyi, P. and Bodosi, M. (1987). Regulation of brain water and electrolyte contents: the possible involvement of central atrial natriuretic factor. Neurosurgery, 21, 454–458

    Google Scholar 

  • Duello, T. M., Nett, T. M. and Farquhar, M. G. (1983). Fate of gonadotropin-releasing hormone agonist internalized by rat pituitary gonadotrophs. Endocrinology, 112, 1–10

    Google Scholar 

  • Fiscus, R. R., Robles, B. T., Waldman, S. A. and Murad, F. (1987). Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. J. Neurochem., 48, 522–528

    Google Scholar 

  • Fitts, D. A., Thunhorst, R. L. and Simpson, J. B. (1985). Diuresis and reduction of salt appetite by lateral ventricular infusions of atriopeptin II. Brain Res., 348,118–124

    Google Scholar 

  • Friedl, A., Harmening, C. and Hamprecht, B. (1986). Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines. J. Neurochem., 46, 1522–1527

    Google Scholar 

  • Friedl, A., Harmening, C, Schuricht, B. and Hamprecht, B. (1985). Rat atrial natriuretic peptide elevates the level of cyclic GMP in astroglia-rich brain cell cultures. Eur. J. Pharmacol, 111, 141–142

    Google Scholar 

  • Fuchs, E., Shigematsu, K. and Saavedra, J. (1986). Binding sites of atrial natriuretic peptide in tree shrew adrenal gland. Peptides, 7, 873–876

    Google Scholar 

  • Fujio, N., Ohashi, M., Nawata, H., Kato, K.-L, Tateishi, J., Matsuo, H. and Ibayashi, H. (1987). Unique distribution of atrial hormones in dog brain. Regulat. Pept., 18, 131–137

    Google Scholar 

  • Fuller, F., Porter, J. G., Arfsten, A. E., Miller, J., Schilling, J. W., Scarborough, R. M., Lewicki, J. A. and Schenk, D. B. (1988). Atrial natriuretic peptide clearance receptor. Complete sequence and functional expression of cDNA clones. J. Biol. Chem., 263,9395–9401 Garcia, R., Cantin, M., Thibault, G., Ong, H. and Genest, J. (1982). Relationship of specific granules to the natriuretic and diuretic activity of rat atria. Experientia, 38, 1071–1073

    Google Scholar 

  • Gardner, D. G., Deschepper, C. F., Ganong, W. F., Hane, S., Fiddes, J., Baxter, J. D. and Lewicki, J. (1986). Extra-atrial expression of the gene for atrial natriuretic factor. Proc. Natl Acad. Sci. USA, 83, 6697–6701

    Google Scholar 

  • Gardner, D. G., Vlasuk, G. P., Baxter, J. D., Fiddes, J. C. and Lewicki, J. A. (1987). Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat. Proc. Natl Acad. Sci. USA, 84, 2175–2179

    Google Scholar 

  • Gibson, T. R., Wildey, G. M., Manaker, S. and Glembotski, C. C. (1986). Autoradiographic localization and characterization of atrial natriuretic peptide binding sites in the rat central nervous system and adrenal gland. J. Neurosci., 6, 2004–2011

    Google Scholar 

  • Glembotski, C. C, Wildey, G. M. and Gibson, T. R. (1988). Biochemical studies of soluble ANF receptors from rat olfactory bulb and vascular smooth muscle cells. Cell. Mol. Neurobiol. (in press)

    Google Scholar 

  • Goedert, M., Mantyh, P. W., Emson, P. C. and Hunt, S. P. (1984). Inverse relationship between neurotensin receptors and neurotensin-like immunoreactivity in the cat striatum. Nature, 307, 543–546

    Google Scholar 

  • Goetz, K. L. (1988). Physiology and pathophysiology of atrial peptides. Am. J. Physiol, 254, E1–E15

    Google Scholar 

  • Goodfriend, T. L., Elliot, M. E. and Atlas, S. A. (1984). Action of synthetic atrial natriuretic factor on bovine adrenal glomerulosa. Life Sci., 35, 1675–1682

    Google Scholar 

  • Gutkowska, J. and Cantin, M. (1988). Bioactive ANF-like peptides in rat anterior pituitary. Can. J. Physiol. Pharmacol., 66, 270–275

    Google Scholar 

  • Gutkowska, J., Racz, K., Debinski, W., Thibault, G., Garcia, R., Kuchel, O., Cantin, M. and Genest, J. (1987). An atrial natriuretic factor-like activity in rat posterior hypophysis. Peptides, 8, 461–465

    Google Scholar 

  • Hamet, P., Tremblay, J., Pang, S. C, Skuherska, R., Schiffin, E. L., Garcia, R., Cantin, M., Genest, J., Palmour, R., Ervin, F. R., Martin, S. and Goldwater, R. (1986). Cyclic GMP as mediator and biological marker of atrial natriuretic factor. J. Hypertension, 4, S49–S56

    Google Scholar 

  • Hashimoto, K., Hattori, T., Suemaro, S., Sugawara, M., Takao, T., Kageyama, J. and Ota, Z. (1987). Atrial natriuretic peptide does not affect corticotropin-releasing factor-, arginine vasopressin- and angiotensin II-induced adrenocorticotropin hormone release in vivo and in vitro, Regulat. Pept, 17, 53–60

    Google Scholar 

  • Haskins, J. T., Zingaro, G. J. and Lappe, R. W. (1986). Rat atriopeptin III alters hypothalamic neuronal aotivity. Neurosci. Lett., 67, 279–284

    Google Scholar 

  • Hattori, Y., Kasai, M., Uesugi, S., Kawata, M. and Yamashita, H. (1988). Atrial natriuretic polypeptide depresses angiotensin II induced excitation of neurons in the rat subfornical organ in vitro. Brain Res., 443, 355–359

    Google Scholar 

  • Heisler, S., Israel-Assayag, E. and Morel, G. (1987). Exposure of AtT-20 corticotrophs to atrial natriuretic factor (ANF) results in desensitization of ANF-induced cGMP formation and ANF internalization. In Biologically Active Atrial Peptides, Vol. 1 (eds B. M. Brenner and J. H. Laragh). Raven Press, New York, pp. 263–265

    Google Scholar 

  • Heisler, S. and Morrier, E. (1988). Bovine adrenal medullary cells contain functional atrial natriuretic peptide receptors, Biochem. Biophys. Res. Commun., 150, 781–788

    Google Scholar 

  • Heisler, S., Simard, J., Assayag, E., Mehri, Y. and Labrie, F. (1986). Atrial natriuretic factor does not affect basal, forskolin- and CRF-stimulated adenylate cyclase activity, cAMP formation or ACTH secretion but does stimulate cGMP synthesis in anterior pituitary. Molec. Cell, Endocrinol, 44, 125–131

    Google Scholar 

  • Hemming, F., Mesguich, P., Morel, G. and Dubois, P. M. (1983). Cryoultramicrotomy versus plastic embedding: comparative immunocytochemistry of rat anterior pituitary cells. J. Microsc, 131,26–34

    Google Scholar 

  • Hernandez, D. E., Simons, K. B., Jennes, L. and Clydey, V. L. (1988). Pupillary response to atrial natriuretic factor in rabbits. Neuropeptides, 12, 219–224

    Google Scholar 

  • Holmes, K. M., Hurley, K. M. and Saper, C. B. (1988). Localization of atrial and brain natriuretic peptides in the rat brain. Soc. Neurosci. Abstr., 14, 354

    Google Scholar 

  • Horvath, J., Ertl, T. and Schally, A. V. (1986). Effect of atrial natriuretic peptide on gonadotropin release in superfused rat anterior pituitary cells. Proc. Natl Acad. Sci. USA, 83, 3444–3446

    Google Scholar 

  • Iitaki, K., Share, L., Crofton, J. T., Brooks, D. P., Ouchi, Y. and Blaine, E. H. (1986). Central atrial natriuretic factor reduces vasopressin secretion in the rat. Endocrinology, 119, 438–440

    Google Scholar 

  • Inagaki, S., Kubota, Y., Kito, S., Kangawa, K. and Matsuo, H. (1986a). Immunoreactive atrial natriuretic polypeptides in the adrenal medulla and sympathetic ganglia. Regulat. Pept., 15, 249–260

    Google Scholar 

  • Inagaki, S., Kobuta, Y., Kito, S., Kangwah, T. and Matsuo, M. (1986b). Atrial natriuretic polypeptide-like immunoreactivity in the rat pituitary: light and electron microscopic studies. Regulat. Pept., 14, 101–111

    Google Scholar 

  • Itoh, H., Nakao, K., Katsuura, G., Morii, N., Shiomo, S., Sakamoto, M., Yamada, T., Saito, Y., Matsushita, A., Katsuura, G., Shiomi, T., Eigyo, M. and Imura, H. (1986a). Centrally infused atrial natriuretic polypeptide attenuates exaggerated salt appetite in spontaneously hypertensive rats. Circ. Res., 59, 342–347

    Google Scholar 

  • Itoh, H., Nakao, K., Katsuura, G., Morii, N., Shiono, S., Yamada, T., Sugawara, A., Saito, Y., Watanabe, K., Igano, K., Inouye, K. and Imura, H. (1987). Atrial natriuretic polypeptides: structure-activity relationship in the central action—a comparison of their antidipsogenic actions. Neurosci. Lett., 74, 102–106

    Google Scholar 

  • Itoh, H., Nakao, K., Katsuura, G., Morii, N., Yamada, T., Shiono, S., Sakamoto, M., Sugawara, A., Saito, Y., Eigyo, M., Matsushita, A. and Imura, H. (1986b). Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamic-pituitary-adrenal axis in conscious rats. Neurosci. Lett., 69, 254–258

    Google Scholar 

  • Itoh, H., Nakao, K., Morii, N., Yamada, T., Shiono, S., Sakamoto, M., Sugawara, A., Saito, Y., Katsuura, G., Shiomi, T., Eigyo, M., Matsushita, A. and Imura, H. (1986c). Central action of atrial natriuretic polypeptides on blood pressure in conscious rats. Brain Res. Bull, 16, 745–749

    Google Scholar 

  • Itoh, H., Nakao, K., Yamada, T., Morii, N., Shiono, S., Sugawara, A., Saito, Y., Mukoyama, M., Arai, H. and Imura, H. (1988a). Central interaction of brain atrial natriuretic polypeptide (ANF) system and brain renin-angiotensin system in ANF secretion from heart. Evidence for possible brain-heart axis. Can. J. Physiol. Pharmacol., 66, 255–261

    Google Scholar 

  • Itoh, H., Nakao, K., Yamada, T., Shirakami, G., Kangawa, K., Minamino, N., Matsuo, H. and Imura, H. (1988b). Antidipsogenic action of a novel peptide, ‘brain natriuretic peptide’, in rats. Eur. J. Pharmacol, 150, 193–196

    Google Scholar 

  • Januszewicz, F., Gutkowska, J., De Lean, A., Thibault, G., Garcia, R., Genest, J. and Cantin, M. (1985). Synthetic atrial natriuretic factor induces release (possibly receptor mediated) of vasopressin from rat posterior pituitary. Proc. Soc. Exp. Biol. Med., 178, 321–325

    Google Scholar 

  • Januszewicz, F., Thibault, G., Garcia, R., Gutkowska, J., Genest, J. and Cantin, M. (1986). Effect of synthetic atrial natriuretic factor on arginine vasopressin release by the rat hypothalamo-neurohypophyseal complex in organ culture. Biochem. Biophys. Res. Commun., 134, 652–658

    Google Scholar 

  • Katsuura, G., Nakamura, M., Inouye, K., Kono, M., Nakao, K. and Imura, H. (1986). Regulatory role of atrial natriuretic polypeptide in water drinking in rats. Eur. J. Pharmacol., 121, 285–287

    Google Scholar 

  • Kawata, M., Nakao, K., Morii, N., Kiso, Y., Yamashita, H., Imura, H. and Sano, Y. (1985). Atrial natriuretic polypeptide: Topographical distribution in the rat brain by radioimmunoas-say and immunohistochemistry. Neuroscience, 16, 521–546

    Google Scholar 

  • Koch, B., Boudjada, T. and Lutz-Bucher, B. (1988). Characterization of high affinity receptor sites for atrial natriuretic factor in anterior pituitary gland: evidence for the existence of two receptor forms. Biochem. Biophys. Res. Commun., 152, 904–909

    Google Scholar 

  • Kuhar, M. J. and Unnerstall, J. R. (1985). Quantitative receptor mapping by autoradiography. Some current technical problems. Trends Neurosci., 8, 49–53

    Google Scholar 

  • Kurihara, M., Saavedra, J. M. and Shigematsu, K. (1987). Localization and characterization of atrial natriuretic peptide binding sites in discrete areas of rat brain and pituitary gland by quantitative autoradiography. Brain Res., 408, 31–39

    Google Scholar 

  • Lappe, R. W., Dinish, J. L., Bex, F., Michalak, K. and Wendt, R. L. (1986). Effects of atrial natriuretic factor on drinking responses to central angiotensin II. Pharmacol. Biochem. Behav., 24, 1573–1576

    Google Scholar 

  • Lee, J., Feng, J. Q., Malvin, R. L., Huang, B.-S. and Grekin, R. J. (1987). Centrally administered atrial natriuretic factor increases water excretion. Am. J. Physiol, 252, F1011– F1015

    Google Scholar 

  • Leitman, D. C, Andresen, J. W., Kuno, T., Kaminski, Y., Chang, J. K. and Murad, F. (1986). Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells. J. Biol. Chem.,261, 11650–11655

    Google Scholar 

  • Leroux, P. and Pelletier, G. (1984). Radioautographic study of binding and internalization of corticotropin-releasing factor by rat anterior pituitary corticotrophs. Endocrinology, 114, 14–21

    Google Scholar 

  • Levin, E. R., Wever, M. A. and Mills, S. (1988). Atrial natriuretic factor-induced vasodepres-sion occurs through central nervous system. Am. J. Physiol, 255, H616–H622

    Google Scholar 

  • Lyall, F., Balmforth, A. J. and Morton, J. J. (1988). Specific binding of atrial natriuretic peptide increases cyclic GMP levels in human astrocytoma cells. J. Endocrinol., 117, 315–321

    Google Scholar 

  • Lynch, D. R., Braas, K. M. and Snyder, S. H. (1986). Atrial natriuretic factor receptors in rat kidney, adrenal gland, and brain: Autoradiographic localization and fluid balance dependent changes. Proc. NatlAcad. Sci. USA, 83, 3357–3361

    Google Scholar 

  • Maack, T., Suzuki, M., Almeida, F. A., Nussenzveig, D., Scarborough, R. M., McEnroe, G. A. and Lewicki, J. A. (1987). Physiological role of silent receptors for atrial natriuretic factor. Science, N Y., 238, 675–678

    Google Scholar 

  • McCarty, R. and Plunkett, L. M. (1986a). Binding sites for atrial natriuretic factor (ANF) in brain: Alterations in Brattleboro rats. Brain Res. Bull., 17, 767–772

    Google Scholar 

  • McCarty, R. and Plunkett, L. M. (1986b). Binding sites for atrial natriuretic factor (ANF) in brain: Alterations in spontaneously hypertensive rats. Neurochem. Int., 9, 177–184

    Google Scholar 

  • McKenzie, J. C, Tanaka, I., Misono, K. S. and Inagami, T. (1985). Immunocytochemical localization of atrial natriuretic factor in the kidney, adrenal medulla, pituitary and atrium of rat. J. Histochem. Cytochem.,8, 828–839

    Google Scholar 

  • Mantyh, C. R., Kruger, L., Brecha, N. C. and Mantyh, P. W. (1986). Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human. Hypertension, 8, 712–721

    Google Scholar 

  • Mantyh, C. R., Kruger, L., Brecha, N. C. and Mantyh, P. W. (1987). Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. Brain Res., 412, 329–342

    Google Scholar 

  • Mantyh, P. W., Maggio, J. E. and Hunt, S. P. (1984). The autoradiographic distribution of kassinin and substance K binding sites is different from the distribution of substance P binding sites in the rat brain. Eur. J. Pharmacol., 102, 361–364

    Google Scholar 

  • Morel, G., Belles-Isles, M. and Heisler, S. (1987a). Internalization of atrial natriuretic factor by AtT-20 corticotropin secreting cells. Biol. Cell, 59, 235–238

    Google Scholar 

  • Morel, G., Chabot, J.-G., Belles-Isles, M. and Heisler, S. (1988a). Synthesis and internalization of atrial natriuretic factor in anterior pituitary cells. Mol. Cell Endocrinol., 55, 219–231

    Google Scholar 

  • Morel, G., Chabot, J.-G., Garcia-Caballero, T., Gossard, F., Dihl, F., Belles-Isles, M. and Heisler, S. (1988b). Synthesis, internalization and localization of atrial natriuretic peptide in rat adrenal medulla. Endocrinology, 123,149–158

    Google Scholar 

  • Morel, G., Chabot, J.-G., Gossard, F. and Heisler, S. (1989). Is atrial natriuretic peptide synthesized and internalized by gonadotrophs? Endocrinology (in press)

    Google Scholar 

  • Morel, G., Dihl, F., Aubert, M. L. and Dubois, P. M. (1987b). Binding and internalization of native gonadoliberin (GnRH) by anterior pituitary gonadotrophs of the rat. Cell Tiss. Res., 248, 541–550

    Google Scholar 

  • Morel, G. and Dubois, P. M. (1982). Immunocytochemical evidence for gonadoliberin in rat anterior pituitary gland. Neuroendocrinology, 34, 197–206

    Google Scholar 

  • Morel, G., Gourdji, D., Grouselle, D., Brunet, N., Tixier-Vidal, A. and Dubois, P. M. (1985a). Immunocytochemical evidence for in vivo internalization of thyroliberin into rat pituitary target cells. Neuroendocrinology, 41, 312–320

    Google Scholar 

  • Morel, G. and Heisler, S. (1988). Internalization of endogenous and exogenous atrial natriuretic peptide by target tissues. Electron Microsc. Res. (in press)

    Google Scholar 

  • Morel, G., Leroux, P. and Pelletier, G. (1985b). Ultrastructural autoradiographic localization of somatostatin-28 in the rat pituitary gland. Endocrinology, 38, 123–133

    Google Scholar 

  • Morel, G., Mesguich, P., Dubois, M. P. and Dubois, P. M. (1984). Ultrastructural evidence for endogenous growth hormone-releasing factor-like immunoreactivity in the monkey pituitary gland. Neuroendocrinology. 38,123–133

    Google Scholar 

  • Mukhopadhyay, A. K., Bohnet, H. G. and Leidenberger, F. A. (1986). Testosterone production by mouse Leydig cells is stimulated in vitro by atrial natriuretic factor. FEBS Lett., 202, 111–116

    Google Scholar 

  • Murakami, Y., Kato, Y., Tojo, K., Inoue, T., Yanaihara, N. and Imura, H. (1988). Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat. Endocrinology, 122, 2103–2108

    Google Scholar 

  • Nakamura, M., Katsuura, G., Nakao, K. and Imura, H. (1985). Antidipsogenic action of a-human atrial natriuretic polypeptide administered intracerebroventricularly in rats. Neuros-ci. Lett., 58, 1–6

    Google Scholar 

  • Nakao, K., Katsuura, G., Morii, N., Itoh, H., Shiono, S., Yamada, T., Sugawara, A., Sakamoto, M., Saito, Y., Eigyo, M., Matsushita, A. and Imura, H. (1986a). Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats. Eur. J. Pharmacol., 131, 171–178

    Google Scholar 

  • Nakao, K., Morii, N., Itoh, H., Sugawara, A., Sakamoto, M., Yamada, T., Shiono, S., Saito, Y., Katsuura, G., Nakamura, M., Eigyo, M., Matsushita, A., Kawata, M., Sand, Y. and Imura, H. (1986b). Atrial natriuretic polypeptide in brain: Implication in water and electrolyte balance and blood pressure control. In Brain and Blood Pressure Control, Int. Congr. Ser. No. 695 (ed. K. Nakamura). Elsevier Science Publishers, Amsterdam, pp. 195–204

    Google Scholar 

  • Nakao, K., Morii, N., Itoh, H., Yamada, T., Shiono, S., Sugawara, A., Saito, Y., Mukoyama, M., Arai, H., Sakamoto, M. and Imura, H. (1986c). Atrial natriuretic polypeptide in the brain: implication of central cardiovascular control. J. Hypertension, 4, S492–S496

    Google Scholar 

  • Napier, M. A., Vandlen, R. L., Albers-Schomberg, G., Nutt, R. F., Brady, S., Lyle, T., Winquist, R., Faison, E. P., Heinel, L. A. and Blaine, E. H. (1984). Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues. Proc. Natl Acad. Sci. USA, 81, 5946–5950

    Google Scholar 

  • Nathanson, J. A., Hunnicutt, E. and Owen, C. (1987). Atriopeptinsin the eye: receptors, second messengers and effects on intraocular pressure. Invest. Ophthalmol. Vis. Sci., 28(3), 273

    Google Scholar 

  • Netchitailo, P., Feuilloley, M., Pelletier, G., Leboulenger, F., Cantin, M., Gutkowska, J. and Vaudry, H. (1987). Atrial natriuretic factor-like immunoreactivity in the central nervous system of the frog. Neuroscience, 22, 341–359

    Google Scholar 

  • Nguyen, T.-T., Ong, H. and De Lean, A. (1988). Secretion and biosynthesis of atrial natriuretic factor by cultured adrenal chromaffin cells. FEBS Lett., 231, 393–396

    Google Scholar 

  • Niwa, M., Ibaragi, M.-A., Tsutsumi, K., Kurihara, M., Himeno, A., Mori, K. and Ozaki, M. (1988). Specific atrial natriuretic peptide binding sites in rat cerebral capillaries. Neurosci. Lett., 91, 89–94

    Google Scholar 

  • Obana, K., Naruse, M., Inagami, T., Brown, A. B., Naruse, K., Kurimoto, F., Sakurai, H., Demura, H. and Shizume, K. (1985). Atrial natriuretic factor inhibits vasopressin secretion from rat posterior pituitary. Biochem. Biophys. Res. Commun., 132, 1088–1094

    Google Scholar 

  • Ohashi, M., Fujio, N., Kato, K., Nawata, A., Ibayashi, H. and Matsuo, H. (1986). Effect of human A-atrial natriuretic polypeptide in adrenocortical function in man. J. Endocrinol., 110, 287–292

    Google Scholar 

  • Okuya, S. and Yamashita, H. (1987). Effects of atrial natriuretic polypeptide on rat hypothala-mic neurons in vitro. J. Physiol., 389, 717–728

    Google Scholar 

  • Olins, G. M., Patton, D. R., Tjoeng, F. S. and Blehm, D. J. (1986). Specific receptors for atriopeptin III in rabbit lung. Biochem. Biophys. Res. Commun., 140, 302–307

    Google Scholar 

  • Ong, H., Lazure, C, Nguyen, T. T., McNicoll, N., Seidah, H., Chretien, M. and De Lean, A. (1987). Bovine adrenal chromaffin granules are a site of synthesis of atrial natriuretic factor. Biochem. Biophys. Res. Commun., 147, 957–963

    Google Scholar 

  • Pandey, K., Inagami, T. and Misono, K. S. (1987). Three distinct forms of atrial natriuretic factor receptors: kidney tubular epithelium cells and vascular smooth muscle cells contain different types of receptors. Biochem. Biophys. Res. Commun., 147, 1146–1152

    Google Scholar 

  • Pandey, K. N., Pavlou, S. M., Kovacs, W. J. and Inagami, T. (1986). Atrial natriuretic factor regulates steroidogenic responsiveness and cyclic nucleotide levels in mouse Leydig cells in vitro. Biochem. Biophys. Res. Commun., 138, 399–404

    Google Scholar 

  • Pelletier, G., Dube, D., Guy, J., Seguin, C. and Lefebvre, F. A. (1982). Binding and internalization of a luteinizing hormone-releasing hormone agonist by gonadotropic cells. A radioautographic study. Endocrinology, 111, 1068–1076

    Google Scholar 

  • Pruss, R. M. and Zamir, N. (1987). Regulated expression of atrial natriuretic peptide-like immunoreactivity in cultured bovine adrenomedullary chromaffin cells. Neuroendocrinology, 41, 299–304

    Google Scholar 

  • Quirion, R. (1986). Atrial natriuretic factors: The brain-heart peptides. In Neural and Endocrine Peptides and Receptors (ed. T. W. Moody). Plenum Publishing Corporation, New York, pp. 299–312

    Google Scholar 

  • Quirion, R. (1988). Atrial natriuretic peptides and the brain: An update. Trends Neurosci., 11, 58–62

    Google Scholar 

  • Quirion, R. (1989). Receptor sites for atrial natriuretic factors in brain and associated structures: an overview. Cell. Molec. Neurobiol. (in press)

    Google Scholar 

  • Quirion, R., Dalpe, M. and Dam, T. V. (1986). Characterization and distribution of receptors for the atrial natriuretic peptides in mammalian brain. Proc. NatlAcad. Sci. USA, 83,174–178

    Google Scholar 

  • Quirion, R., Dalpé, M. and De Lean, A. (1988). Characterization, distribution and plasticity of atrial natriuretic factor binding sites in brain. Can. J. Physiol. Pharmacol., 66, 280–287

    Google Scholar 

  • Quirion, R., Dalpé, M., De Lean, A., Gutkowska, J., Cantin, M. and Genest, J. (1984). Atrial natriuretic factor (ANF) binding sites in brain and related structures. Peptides, 5, 1167–1172

    Google Scholar 

  • Ricard, B., Fourquet, P., Massacrier, A. and Couraud, F. (1988). Photoaffinity labeling of ANF receptor in cultured brain neurones. Biochem. Biophys. Res. Commun., 152, 1031–1037

    Google Scholar 

  • Saavedra, J. M. (1987). Regulation of atrial natriuretic peptide receptors in the rat brain. Cell. Molec. Neurobiol, 7, 151é2013;179

    Google Scholar 

  • Saavedra, J. M. (1988). Brain atrial natriuretic peptide receptors. ISI Atlas of Science, Pharmacology, 2, 287–293

    Google Scholar 

  • Saavedra, J. M., Correa, F. M. A., Plunkett, L. M., Israel, A., Kurihara, M. and Shigematsu, K. (1986a). Binding of angiotensin and atrial natriuretic peptide in brain of hypertensive rats. Nature, 320, 758–760

    Google Scholar 

  • Saavedra, J. M., Israel, A., Correa, F. M. A. and Kurihara, M. (1986b). Increased atrial natriuretic peptide (6–33) binding sites in the subfornical organ of water deprived and Brattleboro rats. Proc. Soc. Exp. Biol. Med., 182, 559–563

    Google Scholar 

  • Saavedra, J. M., Israel, A. and Kurihara, M. (1987). Increased atrial natriuretic peptide binding sites in the rat subfornical organ after water deprivation. Endocrinology, 120, 426–428

    Google Scholar 

  • Saavedra, J. M., Israel, A., Kurihara, M. and Fuchs, E. (1986c). Decreased number and affinity of rat atrial natriuretic peptide6.33 in the subfornical organ of spontaneously hypertensive rats. Circ. Res., 58, 389–392

    Google Scholar 

  • Samson, W. K. (1985a). Atrial natriuretic factor inhibits dehydration and hemorrhage-induced vasopressin release. Neuroendocrinology, 40 277–279

    Google Scholar 

  • Samson, W. K. (1985b). Dehydration-induced alterations in rat brain vasopressin and atrial natriuretic factor immunoreactivity. Endocrinology, 117, 1279–1281

    Google Scholar 

  • Samson, W. K. and Bianchi, R. (1988). Further evidence for a hypothalamic site of action of atrial natriuretic factor: inhibition of prolactin secretion in the conscious rat. Can. J. Physiol. Pharmacol, 66,301–305

    Google Scholar 

  • Saper, C. B., Standaert, D. G., Currie, M. G., Schwartz, D., Geller, D. M. and Needleman, P. (1985). Atriopeptin-immunoreactive neurons in the brain: Presence in cardiovascular regulatory areas. Science, N.Y.,221,1047–1049

    Google Scholar 

  • Scarborough, R. M., Schenk, D. B., McEnroe, G. A., Arfsten, A., Kang, L.-L., Schwartz, K. and Lewicki, J. A. (1986). Truncated atrial natriuretic peptide analogs: comparison between receptor binding and stimulation of cyclic GMP accumulation in cultured vascular smooth muscle cells. J. Biol. Chem., 261, 12960–12964

    Google Scholar 

  • Shibasaki, T., Naruse, M., Naruse, K., Masuda, A., Kim, Y. S., Imaki, T., Yamauchi, N., Demura, H., Inagami, T. and Shizune, K. (1986). Atrial natriuretic factor is released from rat hypothalamus in vitro. Biochem. Biophys. Res. Commun., 136, 590–595

    Google Scholar 

  • Shigematsu, K., Kurihara, M., Niwa, M., Nakao, K., Kataoka, Y., Maeda, T., Tsuchiyama, H., Ozaki, M., Imura, H. and Matsuo, M. (1988). Autoradiographic evidence of porcine brain natriuretic peptide binding sites in the porcine and rat brain, adrenal gland and kidney. Soc. Neurosci. Abstr., 14, 782

    Google Scholar 

  • Sills, M. A., Nguyen, K. Q. and Jacobowitz, D. M. (1985). Increases in heart rate and blood pressure produced by microinjections in atrial natriuretic factor into the AV3V region of rat brain. Peptides, 6,1037–1042

    Google Scholar 

  • Simard, J., Hubert, F. F., Labrie, F., Assayag, E. and Heisler, S. (1986). Atrial natriuretic factor-induced cGMP accumulation in rat anterior pituitary cells in culture is not coupled to hormonal secretion. Regulat. Pept., 15, 269–278

    Google Scholar 

  • Skofitsch, G., Jacobowitz, D. M., Eskay, R. L. and Zamir, N. (1985). Distribution of atrial natriuretic factor-like immunoreactive neurons in the rat brain. Neuroscience, 16, 917–948 Standaert, D. G., Cehcetto, D. F., Needleman, P. and Saper, C. B. (1987). Inhibition of the firing of vasopressin neurons by atriopeptin. Nature, 329, 151–153

    Google Scholar 

  • Standaert, D. G., Needleman, P. and Saper, C. B. (1986). Organization of atriopeptin-like immunoreactive neurons in the central nervous system of the rat. J. Comp. Neurol, 253, 315–341

    Google Scholar 

  • Steardo, L. and Nathanson, J. A. (1987). Brain barrier tissues: End organs for atriopeptins. Science, N.Y., 235, 470–473

    Google Scholar 

  • Stenberger, L. A. and Petrali, J. P. (1975). Quantitative immunochemistry of pituitary receptors for luteinizing hormone-releasing hormone. :Cell Tiss. Res., 162,141–146

    Google Scholar 

  • Stone, R. A. and Glembotski, C. C. (1986). Immunoactive atrial natriuretic peptide in the rat eye: Molecular forms in anterior uvea and retina. Biochem. Biophys. Res. Commun., 134, 1022–1028

    Google Scholar 

  • Sudoh, T., Kanagawa, K., Minamino, N. and Matsuo, H. (1988). A new natriuretic peptide in porcine brain. Nature, 332, 78–81

    Google Scholar 

  • Sugiyama, M., Fukumi, H., Grammer, R. T., Misono, K. S., Yabe, Y., Morisawa, Y. and Inagami, T. (1984). Synthesis of atrial natriuretic peptides and studies on structural factors in tissue specificity. Biochem. Biophys. Res. Commun., 123, 338–344

    Google Scholar 

  • Sugrue, M. F. and Viader, M.-P. (1986). Synthetic atrial natriuretic factor lowers rabbit intraocular pressure. Eur. J. Pharmacol, 130, 349–350

    Google Scholar 

  • Takayanagi, R., Grammer, R. T. and Inagami, T. (1986). Regional increase of cyclic GMP by atrial natriuretic factor in rat brain: markedly elevated response in spontaneously hypertensive rats. Life Set, 39, 573–580

    Google Scholar 

  • Tanaka, I. and Inagami, T. (1986). Release of immunoreactive atrial natriuretic factor from rat hypothalamus in vitro. Eur. J. Pharmacol., 122, 353–355

    Google Scholar 

  • Tang, J., Webber, R. J., Chang, D., Chang, J. K., Klang, J. and Wei, E. T. (1984). Depressor and natriuretic activities of several atrial peptides. Regulat. Pept., 9, 53–59

    Google Scholar 

  • Tong, Y. and Pelletier, G. (1987). Ontogenesis of atrial natriuretic factor (ANF) receptors in the rat brain. Abstract No. 22, Symposium on Molecular Biology of Brain and Endocrine Peptidergic Systems, Montreal

    Google Scholar 

  • Tsutsumi, K., Niwa, M., Himeno, A., Kurihara, M., Kawano, T., Ibaragi, M., Ozaki, M. and Mori, K. (1988). a-Atrial natriuretic peptide binding sites in the rat choroid plexus are increased in the presence of hydroephalus. Neurosci. Lett., 87, 93–98

    Google Scholar 

  • Vanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, V., Yazaki, Y., Goto, K. and Masaki, T. (1988). A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 332, 411–415

    Google Scholar 

  • Von Schroeder, H. P., Nishimura, E., Mclntosh, C. H. S., Buchan, A. M. J., Wilson, N. and Ledsome, J. R. (1985). Autoradiographic localization of binding sites for atrial natriuretic factor. Can. J. Physiol. Pharmacol., 63, 1373–1377

    Google Scholar 

  • Wildey, G. M. and Glembotski, C. C. (1986). Cross-linking of atrial natriuretic peptide to binding sites in rat olfactory bulb membranes. J. Neurosci., 6, 3767–3776

    Google Scholar 

  • Wong, M., Samson, W. K., Dudley, C. A. and Moss, R. L. (1986). Direct, neuronal action of atrial natriuretic factor in the rat brain. Neuroendocrinology, 44, 49–53

    Google Scholar 

  • Wynn, P. C, Suarez-Quian, C. A., Childs, G. V. and Catt, K. J. (1986). Pituitary binding and internalization of radioiodinated gonadotropin-releasing hormone agonist and antagonist ligands in vitro and in vivo. Endocrinology, 119,1852–1863

    Google Scholar 

  • Zamir, N., Skofitsch, G., Eskay, R. L. and Jacobowitz, D. M. (1986). Distribution of immunoreactive atrial natriuretic peptides in the central nervous system of the rat. Brain Res., 365, 105–111

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, H4H1R3, 6875 Blvd. LaSalle, Verdun, Quebec, Canada

    Jean-Guy Chabot & RÉMi Quirion

  2. UA559, Laboratoire d’Histologie et Embryologie, Faculté de Médecine Lyon-Sud, CNRS, B.P. 12, 69600, Oullins, France

    Gerard Morel

Authors
  1. Jean-Guy Chabot
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. RÉMi Quirion
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gerard Morel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Nuffield Laboratory of Ophthalmology, University of Oxford, 0X26AW, Oxford, UK

    Neville N. Osborne

Copyright information

© 1990 Macmillan Publishers Limited

About this chapter

Cite this chapter

Chabot, JG., Quirion, R., Morel, G. (1990). Atrial Natriuretic Factors and the Central Nervous System: Receptors and Functions. In: Osborne, N.N. (eds) Current Aspects of the Neurosciences. Palgrave, London. https://doi.org/10.1007/978-1-349-10997-5_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-10997-5_2

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-10999-9

  • Online ISBN: 978-1-349-10997-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation