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Phosphorothioate Oligodeoxynucleotide Analogues

  • Chapter
Oligodeoxynucleotides

Part of the book series: Topics in Molecular and Structural Biology ((TMSB))

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Abstract

Phosphorothioates contain a sulphur-for-oxygen substitution at phosphorus (Figure 5.1). In relation to the need for the development of chimeric oligo analogues for the antisense approach, the substitution of one sulphur atom for one oxygen atom is perhaps the most conservative chemical substitution that can be made at the phosphate moiety.

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Authors
  1. C. A. Stein
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  2. Jack S. Cohen
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Editors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Jack S. Cohen

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© 1989 The Contributors

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Stein, C.A., Cohen, J.S. (1989). Phosphorothioate Oligodeoxynucleotide Analogues. In: Cohen, J.S. (eds) Oligodeoxynucleotides. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-10869-5_6

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