Abstract
The term ‘antisense’ has entered the popular vocabulary as a term denoting a novel approach to chemotherapy. The field that is encompassed by this term has blossomed to such an extent that it has now reached the stage of popularization (Chase, 1988; Kolata, 1988). But the basis for this approach, and the many assumptions and pitfalls involved in it, cannot be dealt with in a limited popular treatment.
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References
Cazenave, C., Stein, C. A., Loreau, N., Thuong, N. T., Neckers, L. M., Subasinghe, C., Hélène, C., Cohen, J. S. and Toulmé, J.-J. (1989). Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides (submitted)
Chase, M. (1988). Promise seen in ‘antisense’ medicine. Wall Street Journal, 22 August
Corey, D. R. and Schultz, P. G. (1987). Generation of hybrid sequence-specific single-stranded deoxyribonuclease. Science N.Y., 238, 1401–1403
Eckstein, F. (1985). Investigation of enzyme mechanisms with nucleoside phosphorothioates. Anal. Biochem., 54, 367–402
Kolata, G. (1988). Cancer researchers seek a genetics strategy. New York Times, 19 April
Matsukura, M., Zon, G., Shinozuka, K., Stein, C. A., Mitsuya, H., Cohen, J. S. and Broder, S. (1988). Phosphorothioate oligodeoxynucleotides as inhibitors of the replication of HIV. Gene, 72, 343–347
Melton, D. A. (Ed.) (1988). Antisense RNA and DNA, Cold Spring Harbor
Stein, C. A. and Cohen, J. S. (1988). Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res., 48, 2659–2668
Toulmé, J.-J. and Hélène, C. (1988). Antimessenger oligodeoxynucleotides: an alternative to antisense RNA for artificial regulation of gene expression — a review. Gene, 72, 51–58
Walder, R. T. and Walder, J. A. (1988). Role of RNase-H in hybrid-arrested translation by antisense oligonucleotides. Proc. Natl Acad. Sci. USA, 85, 5011–5015
Zamecnik, P. and Stephenson, M. (1978). Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl Acad. Sci. USA, 75, 280–284
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Cohen, J.S. (1989). Introduction: Strategies and Realities. In: Cohen, J.S. (eds) Oligodeoxynucleotides. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-10869-5_1
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DOI: https://doi.org/10.1007/978-1-349-10869-5_1
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