• R. L. Holland


The aims of the early phase evaluation of a novel analgesic are to examine kinetics and limits to dosage by side-effects (tolerance), and to establish the therapeutic dose. Kinetics and tolerance studies are common to all novel drugs and are addressed elsewhere in this volume. This chapter will concentrate upon methods to establish efficacy, and then touch upon other pharmacodynamic properties of analgesics which can sometimes be explored.


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Copyright information

© The editors and contributors 1990

Authors and Affiliations

  • R. L. Holland
    • 1
  1. 1.Dept of Clinical ResearchDuphar BVWeespThe Netherlands

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