Abstract
Toxicity testing in the early phases of drug development has three main purposes: (1) to demonstrate toxic effects and the circumstances of their occurrence; (2) to show what toxic effects did not occur; (3) to suggest whenever possible the likely mechanisms of toxicity. From all these findings and analyses, a cautious prediction can be made of the possible nature and incidence of toxic effects in man, so that likely risks can be matched against anticipated benefits of treatment.
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Dayan, A. (1990). The Toxicological Background. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_4
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DOI: https://doi.org/10.1007/978-1-349-10705-6_4
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