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Hypnotics

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Early Phase Drug Evaluation in Man

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Abstract

The term ‘hypnotic’ is derived from the Greek hypnos, meaning ‘sleep’. A hypnotic drug produces drowsiness and promotes the onset and maintenance of sleep. The sleep induced by hypnotic drugs does not resemble the artificial state of suggestibility known as hypnosis. Sedation, sleep and general anaesthesia are generally regarded as being part of the same continuum of central nervous system depression. Thus, high doses of most hypnotic drugs can induce general anaesthesia.

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References

  • Bixler, E. O., Kales, A., Soldatos, C. R., Kales, J. D. and Healey, S. (1979). Prevalence of sleep disorders in the Los Angeles metropolitan area. Am. J. Psychiat., 136, 1257–62

    Article  CAS  PubMed  Google Scholar 

  • Bond, A. J. and Lader, M. H. (1973). The residual effects of flurazepam. Psychopharmacology, 32, 223–35

    Article  CAS  Google Scholar 

  • Brogden, R. N. and Goa, K. L. (1988). Flumazenil. A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use. Drugs, 35, 448–67

    Article  CAS  PubMed  Google Scholar 

  • Duncan, J. (1988). Neuropsychiatric aspects of sedative drug withdrawal. Hum. Psychopharm., 3, 171–80

    Article  CAS  Google Scholar 

  • FDA (1977). Guidelines for the Clinical Evaluation of Hypnotic Drugs. US Government Printing Office, Washington D.C.

    Google Scholar 

  • Feely, M. P. and Haigh, J. R. M. (1988). Differences between benzodiazepines. Lancet, i, 1460

    Article  Google Scholar 

  • Fink, M. (1969). EEG and human psychopharmacology. Ann. Rev. Pharmac., 9, 241–58

    Article  CAS  Google Scholar 

  • Fink, M. (1982). Quantitative pharmaco-EEG to establish dose-time relations in clinical pharmacology. In Herrmann, W. M. (Ed.), Electroencephalography in Drug Research. Gustav Fischer, Stuttgart

    Google Scholar 

  • Harvey, S. C. (1985). Hypnotics and sedatives. In Goodman Gilman, A., Goodman, L. S., Rail, W. and Murad, F. (Eds.), The Pharmacological Basis of Therapeutics, 7th edn. Macmillan, New York

    Google Scholar 

  • Herrmann, W. M. (1982). Development and critical evaluation of an objective procedure for the electroencephalographic classification of psychotropic drugs. In Herrmann, W. M. (Ed.), Electroencephalography in Drug Research. Gustav Fischer, Stuttgart

    Google Scholar 

  • Hindmarch, I. (1980). Psychomotor function and psychoactive drugs. Br. J. Clin. Pharm., 10, 189–209

    Article  CAS  Google Scholar 

  • Itil, T. M. (1974). Quantitative pharmacoelectroencephalography. Use of computerised cerebral biopotentials in psychotropic drug research. In Itil, T. M. (Ed.), Modern Problems of Pharmacopsychiatry. Vol. 8: Psychotropic Drugs and the Human EEG. Karger, Basle

    Google Scholar 

  • Jochemsen, R., van Boxtel, C. J., Hermans, J. and Breimer, D. D. (1983). Pharmacokinetics of 5-benzodiazepine hypnotics in the same panel of healthy subjects. In Clinical Pharmacokinetics of 5-Benzodiazepine Hypnotics. R. Jochemsen Doc. Disc. J. H. Pasmans, The Hague

    Google Scholar 

  • Kales, A., Bixler, E. O., Kales, J. D. and Scharf, M. B. (1977). Comparative effectiveness of nine hypnotic drugs: sleep laboratory studies. J. Clin. Pharm., 17, 207–13

    Article  CAS  Google Scholar 

  • Kales, A., Soldatos, C. R., Bixler, E. O. and Kales, J. D. (1983). Rebound insomnia and rebound anxiety: A review. Pharmacol., 26, 121–37

    Article  CAS  Google Scholar 

  • Lader, M. H. (1986). The use of hypnotics and anxiolytics in the elderly. Int. Clin. Psychopharm., 1, 273–83

    Article  CAS  Google Scholar 

  • Lader, M. H. and Lawson, C. (1987). Sleep studies and rebound insomnia: methodological problems, laboratory findings and clinical implications. Clin. Neuropharm., 10, 291–312

    Article  CAS  Google Scholar 

  • Lee, A. and Lader, M. (1988). Tolerance and rebound during and after short-term administration of quazepam, triazolam and placebo to healthy human volunteers. Int. Clin. Psychopharm., 3, 31–47

    Article  CAS  Google Scholar 

  • McClelland, G. R. (1989). Body sway and psychoactive drugs: a review. Hum. Psychopharm, 4, 3–15

    Article  Google Scholar 

  • McClelland, G. R. and Jackson, D. (1987). Automated testing of the effects of drugs on cognitive function. Presented at XIth International Meeting of Pharmaceutical Physicians, Brighton

    Google Scholar 

  • McClelland, G. R. and Raptopoulos, P. (1986). Paroxetine and amylobarbitone, effects on psychomotor performance. Br. J. Clin. Pharm., 22, 227P–228P

    Google Scholar 

  • Merz, W. A. and Ballmer, W. (1983). Symptoms of barbiturate/benzodiazepine withdrawal syndrome in healthy volunteers: standardised assessment by a newly developed self-rating scale. J. Psychoactive Drugs, 15, 71–84

    Article  CAS  PubMed  Google Scholar 

  • Nicholson, A. N. (1986). Hypnotics and transient insomnia. In O’Hanlon, J. F. and de Gier, J. J. (Eds.), Drugs and Driving. Taylor and Francis, London

    Google Scholar 

  • Parrott, A. C. and Hindmarch, I. (1978). Factor analysis of a sleep evaluation questionnaire. Psychiat. Med., 8, 325–9

    Article  CAS  Google Scholar 

  • Ray, W. A., Griffin, M. R., Schaffner, W., Baugh, D. K. and Melton, L. J. (1987). Psychotropic drug use and the risk of hip fracture. New Engl. J. Med., 316, 363–9

    Article  CAS  PubMed  Google Scholar 

  • Reynolds, E. H., Heller, A. J. and Ring, H. A. (1988). Clobazam for epilepsy. Lancet, ii, 565

    Article  Google Scholar 

  • Saletu, B., Grünberger, J., Taeuber, K. and Nitsche, V. (1982). Relation between pharmacodynamics and -kinetics: EEG and psychometric studies with cinolazepam and nomifensine. In Herrmann, W. M. (Ed.), Electroencephalography in Drug Research. Gustav Fischer, Stuttgart

    Google Scholar 

  • Schmauss, C., Apelt, S. and Emrich, H. M. (1987). Characterization of benzodiazepine withdrawal in high and low dose dependent psychiatric in-patients. Brain Res. Bull., 19, 393–400

    Article  CAS  PubMed  Google Scholar 

  • Spinweber, C. L. and Johnson, L. C. (1982). Effects of triazolam (0.5 mg) on sleep, performance, memory and arousal threshold. Psychopharmacology, 76, 5–12

    Article  CAS  PubMed  Google Scholar 

  • Stanley, R. O., Tiller, J. W. G. and Adrian, J. (1987). The psychomotor effects of single and repeated doses of hypnotic benzodiazepines. Int. Clin. Psychopharm., 2, 317–23

    Article  CAS  Google Scholar 

  • Swift, C. G. (1984). Postural instability as a measure of sedative drug response. Br. J. Clin. Pharm., 18, 875–905

    Article  Google Scholar 

  • WHO (1986). Guidelines for the clinical investigation of psychotropic drugs (WHO). Pharmacopsychiatria, 19, 395–9

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Medical Affairs Dept, Roche Products Ltd, PO Box 8, Welwyn Garden City, Herts, AL7 3AY, UK

    G. R. McClelland & P. J. Summerfield

Authors
  1. G. R. McClelland
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  2. P. J. Summerfield
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Editor information

Editors and Affiliations

  1. May and Baker Pharmaceuticals Rhône-Poulenc Ltd, Dagenham, RM10 7XS, UK

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  2. University of Vienna, Austria

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  3. Clinical Development Unit 1, The Upjohn Company, Kalamazoo, MI, 49001, USA

    Otto I. Linet MD, PhD (Director) (Director)

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© 1990 The editors and contributors

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McClelland, G.R., Summerfield, P.J. (1990). Hypnotics. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_33

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  • DOI: https://doi.org/10.1007/978-1-349-10705-6_33

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-10707-0

  • Online ISBN: 978-1-349-10705-6

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