Skip to main content
SpringerLink
Log in
Book cover

Early Phase Drug Evaluation in Man pp 395–406Cite as

Drugs in Epilepsy

  • Chapter

  • 42 Accesses

Abstract

Epilepsy is a chronic condition but one which manifests itself only intermittently. To achieve adequate control of seizures, drugs must be taken continuously and in the long term. Therefore, the development and testing of drugs for epilepsy poses problems peculiar to the condition. It is the purpose of this chapter to anticipate these problems and to discuss potential strategies in early studies on new drugs for epilepsy.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Capewell, S., Freestone, S., Critchley, J. A. J. H., Pottage, A. and Prescott, L. F. (1988). Reduced felodipine bioavailability in patients taking anticonvulsants. Lancet, 2, 480–2

    Article  CAS  PubMed  Google Scholar 

  • Commission on Classification and Terminology of the International League Against Epilepsy (1981). Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia, 22, 489–501

    Article  Google Scholar 

  • Cramer, J. A., Smith, D. B., Mattson, R. H., Delgado Escuta, A. V., Collins, J. F. and the VA Epilepsy Co-operative Study Group (1983). A method of quantification for the evaluation of antiepileptic drug therapy. Neurology (Cleveland), 33 (Suppl. 1), 26–37

    Article  CAS  Google Scholar 

  • Crawford, P., Ghadiali, E., Lane, R., Blumhardt, L. and Chadwick, D. (1987). Gabapentin as an antiepileptic drug in man. J. Neurol. Neurosurg. Psychiat. 50 (6), 682–6

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Elwes, R. D. C., Johnson, A. L., Shorvon, S. D. and Reynolds, E. H. (1984). The prognosis for seizure control in newly diagnosed epilepsy. New Engl. J. Med., 311 (15), 944–7

    Article  CAS  PubMed  Google Scholar 

  • Monks, A., Boobis, S., Wadsworth, J. and Richens, A. (1978). Plasma protein binding interaction between phenytoin and valproic acid in vitro. Br. J. Clin. Pharm., 6, 487–92

    Article  CAS  Google Scholar 

  • Park, B. K. (1982). Assessment of drug metabolism capacity of the liver. Br. J. Clin. Pharm., 14, 631–51

    Article  CAS  Google Scholar 

  • Reynolds, E. H. (1983). Mental effects of antiepileptic medication—a review. Epilepsia, 24 (Suppl. 2), S85–S95

    Article  PubMed  Google Scholar 

  • Reynolds, E. H., Ring, H. and Heller, A. (1988). A controlled trial of gamma-vinyl gaba (vigabatrin) in drug resistant epilepsy. Br. J. Clin. Pract., 42 (Suppl. 61), 33

    Google Scholar 

  • Sawaya, M. L. B., Horton, R. W. and Meldrum, B. S. (1975). Effects of anticonvulsant drugs on cerebral enzymes metabolising GABA. Epilepsia, 16, 649–55

    Article  CAS  PubMed  Google Scholar 

  • Schmidt, D. (1982a). Adverse Effects of Antiepileptic Drugs. Raven Press, pp. 19–24

    Google Scholar 

  • Schmidt, D. (1982b). Two antiepileptic drugs for intractable epilepsy with complex partial seizures. J. Neurol. Neurosurg. Psychiat., 45, 1119–24

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Treiman, D. M. and Ben-Menachem, E. (1987). Inhibition of carbamazepine and phenytoin metabolism by nafimidone, a new antiepileptic drug. Epilepsia, 28, 699–705

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK

    J. I. Morrow & A. Richens

Authors
  1. J. I. Morrow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Richens
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. May and Baker Pharmaceuticals Rhône-Poulenc Ltd, Dagenham, RM10 7XS, UK

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  2. University of Vienna, Austria

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  3. Clinical Development Unit 1, The Upjohn Company, Kalamazoo, MI, 49001, USA

    Otto I. Linet MD, PhD (Director) (Director)

Copyright information

© 1990 The editors and contributors

About this chapter

Cite this chapter

Morrow, J.I., Richens, A. (1990). Drugs in Epilepsy. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-10705-6_31

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-10707-0

  • Online ISBN: 978-1-349-10705-6

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation