Assessment of Respiratory Responses

  • Timothy W. Evans
  • Peter J. Barnes
Chapter

Abstract

The assessment of responses of the respiratory system to new drugs is dependent upon the particular pathology and condition being treated. The lung can be divided into vascular and parenchymal compartments. Pharmacological manipulation of the pulmonary vasculature is discussed elsewhere. Diseases of the parenchyma involve either the conducting airways, as in asthma or chronic obstructive pulmonary disease (COPD), or the alveoli, interstitium and gas-exchanging membranes, as in pulmonary fibrosis. Drug evaluation in respiratory disease therefore depends upon the assessment of responses to therapies manipulating airflow and airway resistance, lung volumes and gas exchange.

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References

  1. 1.
    Boushey, H. A., Holtzman, M. J., Sheller, J. R. and Nadel, J. A. (1980). State of the art: bronchial hyperreactivity. Am. Rev. Respir. Dis., 121, 389–413PubMedGoogle Scholar
  2. 2.
    Pride, N. B. (1983). Physiology, In Clarke, T. J. H. and Godfrey, S. (Eds.), Asthma. Chapman and Hall, LondonGoogle Scholar
  3. 3.
    Turner-Warwick, M. (1977). On observing patterns of airflow obstruction. Br. J. Dis. Chest, 71, 73–8CrossRefPubMedGoogle Scholar
  4. 4.
    Wagner, P. D., Dantzker, D. R., Iacovoni, V. E., Tomlin, W. C. and West, J. B. (1978). Ventilation-perfusion inequality in asymptomatic asthma. Am. Rev. Respir. Dis., 118, 511–24PubMedGoogle Scholar
  5. 5.
    Dunnill, M. S. (1960). The pathology of asthma with special reference to changes in the bronchial mucosa. J. Clin. Pathol., 13, 27–33PubMedCentralCrossRefPubMedGoogle Scholar
  6. 6.
    Dunnill, M. S. (1980). Pulmonary Pathology. Churchill Livingstone, London, pp. 50–66Google Scholar
  7. 7.
    Gerblich, A. A., Campbell, A. E. and Schuyler, M. R. (1984). Changes in T lymphocyte subpopulations after antigenic bronchial provocation in asthmatics. New Engl. J. Med., 310, 1349–52CrossRefPubMedGoogle Scholar
  8. 8.
    Bouhuys, A., Hunt, V. R., Kim, B. M. and Zapletal, A. (1969). Maximum expiratory flow rates in induced bronchoconstriction in man. J. Clin. Invest., 48, 1159–68PubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Barnes, P. J., Gribben, H. R., Osmanilov, D. and Pride, N. B. (1981). Partial flow-volume curves to measure bronchodilator dose-response curves in normal subjects. J. Appl. Physiol., 50, 1193–7PubMedGoogle Scholar
  10. 10.
    Gyuatt, A. R. and Alpers, J. H. (1968). Factors affecting airways conductance: a study of 752 working men. J. Appl. Physiol., 48, 1159–68Google Scholar
  11. 11.
    Snashall, P. D., Gillet, M. K. and Chung, K. F. (1988). Factors contributing to bronchial hyperresponsiveness in asthma. Clin. Sci., 74, 113–18CrossRefPubMedGoogle Scholar
  12. 12.
    Woolcock, A. J., Salome, C. M. and Yan, K. (1984). The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am. Rev. Resp. Dis., 130, 71–5PubMedGoogle Scholar
  13. 13.
    Chung, K. F., Morgan, B. M., Keyes, S. J. and Snashall, P. D. (1982). Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway calibre. Am Rev. Resp. Dis., 126, 849–54PubMedGoogle Scholar
  14. 14.
    Godfrey, S. (1983). Exercise-induced asthma. In Clark, T. J. H. and Godfrey, S. (Eds.), Asthma. Chapman and Hall, London, pp. 57–78Google Scholar
  15. 15.
    Lee, T. H. (1986). Heat loss, osmolarity and the respiratory epithelium. In Kay, A. B. (Ed.), Asthma: Clinical Pharmacology and Therapeutic Progress. Blackwell Scientific Publications, Oxford, pp. 393–400Google Scholar
  16. 16.
    Assoufi, B. K., Dally, M. B., Newman-Taylor, A. J. and Denison, D. M. (1986). Cold air test: a simplified standard method for airway reactivity. Clin. Resp. Physiol, 22, 349–57Google Scholar
  17. 17.
    Linn, William S., Avol, E. L., Peng, Ru-chuan, Shamoo, D. A. and Hackney, J. D. (1987). Replicated dose-response study of sulfur dioxide effects in normal, atopic and asthmatic volunteers. Am. Rev. Resp. Dis., 136, 1127–34CrossRefPubMedGoogle Scholar
  18. 18.
    Cockcroft, D. W., Ruffin, R. E., Dolovich, J. and Hargreave, F. E. (1977). Allergen-induced increase in non-allergic bronchial reactivity. Clin. Allerg., 7, 503–13CrossRefGoogle Scholar
  19. 19.
    Durham, S. R. and Kay, A. B. (1986). Inflammatory cells and mediators in allergen-induced late phase asthmatic reactions. In Kay, A. B. (Ed.), Asthma: Clinical Pharmacology and Therapeutic Progress. Blackwell Scientific Publications, Oxford, pp. 33–46Google Scholar
  20. 20.
    de Monchy, J. G. R., Kauffman, H. F., Venge, P., Koeter, G. H., Jansen, H. M., Sluiter, H. J. and de Vries, K. (1985). Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am. Rev. Resp. Dis., 131, 373–6PubMedGoogle Scholar
  21. 21.
    Elwood, R. K., Belzberg, A., Hogg, J. C. and Pare, P. D. (1982). Bronchial mucosal permeability in asthma. Am. Rev. Resp. Dis., 125, 63–7Google Scholar
  22. 22.
    Barrowcliffe, M. P. and Jones, J. G. (1987). Solute permeability of the alveolar capillary barrier. Thorax, 42, 1–10PubMedCentralCrossRefPubMedGoogle Scholar
  23. 23.
    Bond, D. and Lader, M. (1974). The use of analogue scales in rating subjective feelings. Br. J. Med. Psychol, 47, 211–18CrossRefGoogle Scholar
  24. 24.
    McGavin, C. R., Gupya, S. P. and McHardy, G. J. R. (1976). Twelve minute walking test for assessing disability in chronic bronchitis. Br. Med. J., i, 822–3CrossRefGoogle Scholar
  25. 25.
    Turner-Warwick, M. (1978). Immunology of the Lung. Arnold, LondonGoogle Scholar
  26. 26.
    Turner-Warwick, M. (1984). Do gallium scans, bronchoalveolar lavage and SACE help monitor activity of chronic sarcoidosis during treatment? In Proceedings of the 10th International Conference on Sarcoidosis and Other Granulomatous Disorders, BaltimoreGoogle Scholar

Copyright information

© The editors and contributors 1990

Authors and Affiliations

  • Timothy W. Evans
    • 1
  • Peter J. Barnes
    • 1
  1. 1.National Heart and Lung InstituteLondonUK

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