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Antithrombotic and Thrombolytic Drugs

  • Chapter
Early Phase Drug Evaluation in Man

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Abstract

Thrombotic disease (venous thromboembolism, coronary and cerebral arterial thrombosis), collectively accounts for the majority of deaths in developed countries. Several drugs of venerable lineage are used in the prevention of such events, notably heparin and warfarin (and its congeners), which interfere with the coagulation cascade; aspirin, which inhibits platelet aggregation; and streptokinase, which causes fibrinolysis. These drugs were introduced into clinical practice before present regulatory requirements were formulated, but the information that has been gained about their clinical pharmacology forms a basis for evaluating new drugs that act on the coagulation cascade or on platelets.

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Author information

Authors and Affiliations

  1. Dept of Clinical Pharmacology, Guy’s Hospital, London Bridge, London, SE1, UK

    J. Ritter

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  1. J. Ritter
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Editor information

Editors and Affiliations

  1. May and Baker Pharmaceuticals Rhône-Poulenc Ltd, Dagenham, RM10 7XS, UK

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  2. University of Vienna, Austria

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  3. Clinical Development Unit 1, The Upjohn Company, Kalamazoo, MI, 49001, USA

    Otto I. Linet MD, PhD (Director) (Director)

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© 1990 The editors and contributors

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Ritter, J. (1990). Antithrombotic and Thrombolytic Drugs. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_26

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  • DOI: https://doi.org/10.1007/978-1-349-10705-6_26

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-10707-0

  • Online ISBN: 978-1-349-10705-6

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