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Anti-anginal Drugs

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Abstract

Considerable advances have been made over the past few years in the understanding of the mechanisms responsible for precipitation or exacerbating anginal pain (Maseri, 1983, 1987; Epstein et al., 1988). These advances have modified the therapeutic approach to the syndrome and it seems important to review them before presenting the methods for evaluation of anti-anginal drugs.

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References

  • Adam, W. E. and Stauch, M. (1985). Radionuclide methods. In Abshagen, U. (Ed.), Clinical Pharmacology of Antianginal Drugs. Springer-Verlag, Berlin, pp. 213–37

    Chapter  Google Scholar 

  • American College of Sports Medicine (1986). Guidelines for Exercise Testing and Prescription. Lea and Febiger, Philadelphia

    Google Scholar 

  • American Heart Association. The Committee on Exercise (1972). Exercise Testing and Training of Apparently Healthy Individuals: A Handbook for Physicians. American Heart Association, Dallas

    Google Scholar 

  • Benson, H. and McCallie, D. P. (1979). Angina pectoris and the placebo effect. New Engl. J. Med., 300, 1424–9

    Article  CAS  PubMed  Google Scholar 

  • Boissel, J. P., Philippon, A. M., Gauthier, E., Schbath, J., Destors, J. M. and the B.I.S. Research Group (1986). Time course of long-term placebo therapy effects in angina pectoris. Eur. Heart J., 7, 1030–6

    CAS  PubMed  Google Scholar 

  • Crea, F., Margonato, A., Kaski, J. C., Roohiguey-Plaza, L., Meran, D. O., Davies, G., Chierchia, S. and Maseri, A. (1986). Variability of results during repeat exercise stress testing in patients with stable angina pectoris: role of dynamic coronary flow reserve. Am. Heart J., 112, 249–54

    Article  CAS  PubMed  Google Scholar 

  • Demer, L., Gould, K. L. and Kirkuide, R. (1988). Assessing stenosis severity: coronary flow reserve, collateral function, quantitative coronary arteriography, positron imaging and digital substraction angiography. A review and analysis. Prog. Cardiovasc. Dis., 30, 307–22

    Article  CAS  PubMed  Google Scholar 

  • Detrano, R. and Froelicher, V. F. (1988). Exercise testing: uses and limitations considering recent studies. Prog. Cardiovasc. Dis., 31, 173–204

    Article  CAS  PubMed  Google Scholar 

  • Epstein, S. E., Cannon, R. O., Watson, R. M., Leon, M. B., Bonow, R. O. and Rosing, D. R. (1985). Dynamic coronary obstruction as a cause of angina pectoris: implications regarding therapy. Am. J. Cardiol., 55, 61B–68B

    Article  CAS  PubMed  Google Scholar 

  • Epstein, S. E., Quyyumi, A. A. and Bonow, R. O. (1988). Myocardial ischaemia—silent or symptomatic. New Engl. J. Med., 318, 1038–43

    Article  CAS  PubMed  Google Scholar 

  • Froelicher, V. F. (1984). Exercise Testing and Training. Year Book Medical Publishers, Chicago, pp. 1–23, 38–74

    Google Scholar 

  • Glasser, S. P., Clark, P. I., Lipicky, R. J. and Yusuf, S. (1988). What is the risk of exposing patients with chronic stable exertional angina to placebo in controlled trials of new drugs? Circulation, 78 (Suppl. II), II-99 (abstract)

    Google Scholar 

  • Iskandrian, A. S. and Hakki, A. M. (1985). Thallium-201 myocardial scintigraphy. Am. Heart J., 109, 113–28

    Article  CAS  PubMed  Google Scholar 

  • Kaul, S., Finkelstein, D. M., Homma, S., Leavitt, M., Okada, R. D. and Boucher, C. A. (1988). Superiority of quantitative exercise thallium-201 variables in determining long-term prognosis in ambulatory patients with chest pain: a comparison with cardiac catheterization. J. Am. Coll. Cardiol., 12, 25–34

    Article  CAS  PubMed  Google Scholar 

  • Khurmi, N. S., Bowles, M. J., Kohli, R. S. and Raftery, E. B. (1986). Does placebo improve indexes of effort-induced myocardial ischemia? An objective study in 150 patients with chronic stable angina pectoris. Am. J. Cardiol., 57, 907–11

    Article  CAS  PubMed  Google Scholar 

  • Klocke, F. J., Ellis, A. K. and Canty, J. M. (1987). Interpretation of changes in coronary flow that accompany pharmacologic interventions. Circulation, 75 (Suppl. V), V34–V38

    CAS  PubMed  Google Scholar 

  • Kraupp, O. (1985). Pharmacodynamic principles of action of antianginal drugs. In Abshagen, U. (Ed.), Clinical Pharmacology of Antianginal Drugs. Springer-Verlag, Berlin, pp. 97–115

    Chapter  Google Scholar 

  • Marcus, M. L., Wilson, R. F. and White, C. W. (1987). Methods of measurement of myocardial blood flow in patients: a critical review. Circulation, 76, 245–53

    Article  CAS  PubMed  Google Scholar 

  • Markham, R. V., Winniford, M. D., Firth, B. G., Nicod, P., Dehmen, G. J., Lewis, S. E. and Hillis, L. D. (1983). Symptomatic, electrocardiographic, metabolic, and hemodynamic alterations during pacing-induced myocardial ischemia. Am. J. Cardiol., 51, 1589–94

    Article  PubMed  Google Scholar 

  • Maseri, A. (1983). The changing face of angina pectoris: practical implications. Lancet, 1, 746–9

    Article  CAS  PubMed  Google Scholar 

  • Maseri, A. (1987). Role of coronary artery spasm in symptomatic and silent myocardial ischemia. J. Am. Coll. Cardiol., 9, 249–62

    Article  CAS  PubMed  Google Scholar 

  • Nestico, P. F., Hakki, A. H. and Iskadrian, A. S. (1985). Effects of cardiac medications on ventricular performance: emphasis on evaluation with radionuclide angiography. Am. Heart J., 109, 1070–84

    Article  CAS  PubMed  Google Scholar 

  • Nienaber, C. and Bleifeld, W. (1985). Assessment of coronary artery disease and myocardial ischemia by invasive methods. In Abshagen, U. (Ed.), Clinical Pharmacology of Antianginal Drugs. Springer-Verlag, Berlin, pp. 239–84

    Chapter  Google Scholar 

  • Parisi, A. F., Strauss, W. E., McIntyre, K. M. and Sasahara, A. A. (1982). Considerations in evaluating new antianginal drugs. Circulation, 65 (Suppl. I), 138–142

    Google Scholar 

  • Reiber, J. H. C., Serruys, P. W., Kooijman, C. J., Wijns, W., Slager, C. J., Gerbrands, J. J., Schnurbiers, J. C. H., Den Boer, A. and Hugenholtz, P. G. (1985). Assessment of short, medium and long term variations in arterial dimensions from computer-assisted qualification of coronary cineangiograms. Circulation, 71, 280–8

    Article  CAS  PubMed  Google Scholar 

  • Schaper, W., Schaper, J. and Hoffmeister, H. M. (1985). Pathophysiology of coronary circulation and of acute coronary insufficiency. In Abshagen, U. (Ed.), Clinical Pharmacology of Antianginal Drugs. Springer-Verlag, Berlin, pp. 47–96

    Chapter  Google Scholar 

  • WHO (1984). Guidelines for the Clinical Investigation of Antianginal Drugs. Geneva

    Google Scholar 

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Author information

Authors and Affiliations

  1. Rhône-Poulenc Santé, 20 Avenue Raymond Aron, 92165, Antony Cedex, France

    Edmond Roland

Authors
  1. Edmond Roland
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Editor information

Editors and Affiliations

  1. May and Baker Pharmaceuticals Rhône-Poulenc Ltd, Dagenham, RM10 7XS, UK

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  2. University of Vienna, Austria

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  3. Clinical Development Unit 1, The Upjohn Company, Kalamazoo, MI, 49001, USA

    Otto I. Linet MD, PhD (Director) (Director)

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© 1990 The editors and contributors

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Roland, E. (1990). Anti-anginal Drugs. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_22

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  • DOI: https://doi.org/10.1007/978-1-349-10705-6_22

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-10707-0

  • Online ISBN: 978-1-349-10705-6

  • eBook Packages: EngineeringEngineering (R0)

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