Abstract
Over recent decades a revolution in analytical methodology has led to a better understanding of the processes of drug absorption, distribution, metabolism and elimination, allowing pharmacokinetics to emerge as a distinct discipline. The justification for an increased interest in pharmacokinetics is presumably based upon the premise that a drug will be used more appropriately when its behaviour in the body is better understood: a drug’s action must be related in some way to its presence in the body. Sophisticated pharmacokinetic modelling may, in addition, provide some clue to the penetration of drugs into receptor sites outside the plasma compartment.
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McEwen, J., Stevenson, I.H. (1990). Radiolabelled Metabolism Studies in Man. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_20
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DOI: https://doi.org/10.1007/978-1-349-10705-6_20
Publisher Name: Palgrave, London
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