Abstract
When sufficient pressure is applied to the skin, the underlying blood vessels are occluded or partially occluded and oxygen and other nutrients are no longer delivered at a rate sufficient to satisfy the metabolic requirements of the tissues. To survive, the cells must draw upon their stores of energy. Without a circulation, the breakdown products of metabolism accumulate within the interstitial spaces and within the cells. As energy stores run out, the cellular processes begin to fail. Ionic gradients across cellular membranes begin to dissipate and the redistribution of fluid which may occur between the cells and extracellular spaces has consequences which in some situations render recovery impossible.
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Michel, C.C., Gillott, H. (1990). Microvascular Mechanisms in Stasis and Ischaemia. In: Bader, D.L. (eds) Pressure Sores - Clinical Practice and Scientific Approach. Palgrave, London. https://doi.org/10.1007/978-1-349-10128-3_12
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DOI: https://doi.org/10.1007/978-1-349-10128-3_12
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