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5-HT Receptors Mediating Pre-synaptic Autoinhibition in Central Serotoninergic Nerve Terminals

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Serotonin

Abstract

Pre-synaptic 5-HT autoreceptors are receptors which are located on (or at least close to) the axon terminals of serotoninergic neurones. Accordingly, they can be activated by serotonin (5-hydroxytryptamine; 5-HT) released from those terminals on which they are located. It is compatible with this location that 5-HT autoreceptors probably play a physiological role in fine regulation of 5-HT release (and of 5-HT synthesis: Hamon et al., 1973; Sawada and Nagatsu, 1986).

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelms Universität Bonn, Reuterstraße 2b, D-5300, Bonn, Federal Republic of Germany

    M. Göthert

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  1. M. Göthert
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Sydney, Australia

    Ewan J. Mylecharane

  2. Baker Medical Research Institute, Prahran, Australia

    James A. Angus

  3. Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia

    Ivan S. de la Lande

  4. Glaxo Group Research Ltd, Ware, England

    Patrick P. A. Humphrey

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© 1989 The editors and contributors

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Göthert, M. (1989). 5-HT Receptors Mediating Pre-synaptic Autoinhibition in Central Serotoninergic Nerve Terminals. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_7

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