Abstract
Two aspects of the biology of 5-hydroxytryptamine (5-HT) in relation to sympathetic neurones which have been investigated electrophysiologically are the mechanisms by which 5-HT brings about its effect, i.e. the ionic basis of each action, and the identification of the 5-HT receptors involved. The latter requires the development of quantitative pharmacological techniques. This article outlines some of the approaches that have proved useful, and touches on the relationship between information from extracellular recording and from intracellular measurements of 5-HT actions on single neurones. Reference is made to some recent experiments on guinea-pig ganglia conducted at Loyola University.
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Wallis, D.I., Dun, N.J. (1989). Electrophysiological Investigation of the Actions of 5-Hydroxytryptamine on Sympathetic Ganglionic Neurones. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_4
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DOI: https://doi.org/10.1007/978-1-349-10114-6_4
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