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Serotonin pp 136–145Cite as

Palgrave Macmillan

Pre-synaptic Sympathetic Inhibition and 5-Hydroxytryptamine-induced Vasodilatation

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Abstract

Within 5 years of the isolation of the serum vasoconstrictor factor, 5-hydroxytryptamine (5-HT), its vasodilating properties had been recognized; Haddy (1953) described 5-HT-induced vasodilation in the forelimb in anaesthetized dogs. A real understanding of the mechanisms responsible for the vasodilator effects of 5-HT, however, has taken a much longer time to emerge.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia

    E. J. Mylecharane & C. A. Phillips

Authors
  1. E. J. Mylecharane
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  2. C. A. Phillips
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Sydney, Australia

    Ewan J. Mylecharane

  2. Baker Medical Research Institute, Prahran, Australia

    James A. Angus

  3. Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia

    Ivan S. de la Lande

  4. Glaxo Group Research Ltd, Ware, England

    Patrick P. A. Humphrey

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© 1989 The editors and contributors

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Mylecharane, E.J., Phillips, C.A. (1989). Pre-synaptic Sympathetic Inhibition and 5-Hydroxytryptamine-induced Vasodilatation. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_18

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