The Modulation of Dopamine Receptor Sensitivity by Thyroid Hormones: A Behavioural and Neurochemical Investigation

  • Ann D. Crocker
  • Donald L. Cameron
Part of the Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology book series (SSNIC)


Several clinical observations are consistent with the hypothesis that there are changes in dopamine receptor activity associated with changes in thyroid hormone status. Thus, there have been reports of a psychiatric disorder in hypothyroid patients which was indistinguishable from paranoid schizophrenia, called myxoedema psychosis, (Asher, 1949). Conversely, in hyperthyroid patients the phenomenon of hyperthyroid choreoathetosis (Hefron and Eaton, 1970) has been reported. These observations stimulated us to investigate dopamine (DA) receptor activity in rats whose thyroid hormone status had been modified, with the aims of establishing if there are associated changes in behavioural responsiveness to DA receptor agonists and what the underlying neurochemical mechanisms might be.


Dopamine Receptor Sodium Fluoride Hypothyroid Group Stimulate cAMP Production Thyroid Hormone Status 
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  1. Asher, R. (1949). Myxoedematous madness. Br. Med. J. 555–562.Google Scholar
  2. Battaglia, G., Norman, A., Hess, E. and Creese, I. (1986).Recovery of D1 DA receptor stimulation of adenylate cyclase. Neurosci. Lett. 69, 290–295.CrossRefPubMedGoogle Scholar
  3. Cameron, D. L. and Crocker, A. D. (1987). Behavioural responses to a selective D2 agonist, LY 171555, in rats with modified thyroid status. Clin. Exp. Pharmacol. Physiol. Supp., 10, 111.Google Scholar
  4. Cameron, D. L. and Crocker, A. D. (1986). A fixed interval momentary sampling method for assessing behaviours induced by DA receptor agonists. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. (in press).Google Scholar
  5. Cameron, D. L. and Crocker, A.D. (1987a). Post-synaptic changes and increased dopamine receptor sensitivity in hypothyroid rats. Pharmacol Biochem Behav., 28, (in press).Google Scholar
  6. Crocker, A. D., Overstreet, D. H. and Crocker, J. M. (1982). Modulation of dopamine receptor sensitivity by thyroid hormones in the rat. Proc. 13th C.I.N.P. Congress, 129.Google Scholar
  7. Crocker, A. D. and Overstreet, D. H. (1984). Modification of the behavioural effects of haloperidol and of dopamine receptor regulation by altered thyroid status. Psychopharmacology, 82, 102–106.CrossRefPubMedGoogle Scholar
  8. Crocker, A. D., Overstreet, D. H. and Crocker, J. M. (1986).Hypothyroidism leads to increased dopamine receptor sensitivity and concentration. Pharmacol Biochem Behav., 24, 1593–1597.CrossRefPubMedGoogle Scholar
  9. Crocker, A. D. and Cameron, D. L. Evidence for post-synaptic changes mediating increased behavioural sensitivity to dopamine receptor agonists in hypothyroid rats. Prog. Neuro-Psychopharmacol.& Biol. Psychiat., (in press).Google Scholar
  10. Hefron, W. and Eaton, R. (1970). Thyrotoxicosis presenting as choreoathetosis. Ann. Int. Med., 73, 425–428.CrossRefGoogle Scholar
  11. Overstreet, D.H., Crocker, A. D., Lawson, C.A., Mcintosh, G. H. and Crocker, J. M. (1984). Alterations in the dopaminergic system and behaviour in rats reared in iodine-deficient diets. Pharmacol. Biochem. Behav., 21, 561–565.CrossRefPubMedGoogle Scholar
  12. Overstreet, D. H., Joschko, M. A., Harris, P. F. and Crocker, A. D. (1984a). The regulation of striatal dopamine receptors: sub-sensitivity induced by hyperthyroidism or REM sleep deprivation. In Basal Ganglia: Structure and Function (eds. J. S. Mackenzie, R. E. Kemm and L. N. Wilcock), 297–318, Plenum, New York.CrossRefGoogle Scholar

Copyright information

© Ann D. Crocker and Donald L. Cameron 1988

Authors and Affiliations

  • Ann D. Crocker
    • 1
  • Donald L. Cameron
    • 1
  1. 1.Department of Clinical Pharmacology and Centre for NeuroscienceFlinders University of South AustraliaAustralia

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