The Modulation of Dopamine Receptor Sensitivity by Thyroid Hormones: A Behavioural and Neurochemical Investigation
Several clinical observations are consistent with the hypothesis that there are changes in dopamine receptor activity associated with changes in thyroid hormone status. Thus, there have been reports of a psychiatric disorder in hypothyroid patients which was indistinguishable from paranoid schizophrenia, called myxoedema psychosis, (Asher, 1949). Conversely, in hyperthyroid patients the phenomenon of hyperthyroid choreoathetosis (Hefron and Eaton, 1970) has been reported. These observations stimulated us to investigate dopamine (DA) receptor activity in rats whose thyroid hormone status had been modified, with the aims of establishing if there are associated changes in behavioural responsiveness to DA receptor agonists and what the underlying neurochemical mechanisms might be.
KeywordsDopamine Iodine Fluoride Schizophrenia Catecholamine
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