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The Modulation of Dopamine Receptor Sensitivity by Thyroid Hormones: A Behavioural and Neurochemical Investigation

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Pharmacology and Functional Regulation of Dopaminergic Neurons

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Abstract

Several clinical observations are consistent with the hypothesis that there are changes in dopamine receptor activity associated with changes in thyroid hormone status. Thus, there have been reports of a psychiatric disorder in hypothyroid patients which was indistinguishable from paranoid schizophrenia, called myxoedema psychosis, (Asher, 1949). Conversely, in hyperthyroid patients the phenomenon of hyperthyroid choreoathetosis (Hefron and Eaton, 1970) has been reported. These observations stimulated us to investigate dopamine (DA) receptor activity in rats whose thyroid hormone status had been modified, with the aims of establishing if there are associated changes in behavioural responsiveness to DA receptor agonists and what the underlying neurochemical mechanisms might be.

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References

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Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University of South Australia, SA, 5042, Australia

    Ann D. Crocker & Donald L. Cameron

Authors
  1. Ann D. Crocker
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  2. Donald L. Cameron
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Editor information

Editors and Affiliations

  1. Clinical Pharmacology and Therapeutics Unit, Austin Hospital, University of Melbourne, Heidelberg, Australia

    P. M. Beart

  2. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK

    G. N. Woodruff

  3. Department of Pharmacology, University of Sydney, Australia

    D. M. Jackson

Copyright information

© 1988 Ann D. Crocker and Donald L. Cameron

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Crocker, A.D., Cameron, D.L. (1988). The Modulation of Dopamine Receptor Sensitivity by Thyroid Hormones: A Behavioural and Neurochemical Investigation. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_50

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