Abstract
Cholecystokinin (CCK), a peptide hormone found originally in the pancreas and gastrointestinal tract, has now been demonstrated to exist in high concentration in various areas of the central nervous system (CNS). The predominant form of CCK in the brain is the sulfated carboxy-terminal octapeptide (CCK-8S); only negligible amounts of the unsulfated form (CCK-8US) have been detected. Ample evidence suggests that CCK-8S may function as a neurotransmitter or modulator in the CNS (for review, see Vanderhaeghen and Crawley, 1985).
This research was supported by USPHS Grants MH-41440, MH-41696 and MH-00378 (RSDA) to R.Y.W. We thank Jane Blanchard for technical assistance, Judith Shivak for typing the manuscript, and E.R. Squibb and Rotta for generous supplies of CCK and lorglumide, respectively.
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© 1988 Rex Y. Wang, Xiu-Ti Hu and Richard J. Kasser
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Wang, R.Y., Hu, XT., Kasser, R.J. (1988). Interactions between Cholecystokinin and Dopamine: Electrophysiological Studies. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_46
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