Skip to main content

Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine

  • Chapter

Abstract

Phencyclidine (PCP) is an abused drug which produces untoward side-effects (violent behavior, hallucinations and paranoia) resembling certain forms of schizophrenia (Rawson et al., 1981). Understanding its mechanism of action may lead to the development of therapies to block its side-effects and may provide a basis for understanding the causes of schizophrenia.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ary, T.E. and Komiskey, H.L. (1982). Phencyclidine-induced release of [3H]-dopamine from chopped striatal tissue. Neuropharmacol., 21, 639–645.

    Article  CAS  Google Scholar 

  • Bowyer, J.F., Spuhler K.P. and Weiner, N. (1984). Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes. J. Pharmacol. Exp. Ther., 229, 671–680.

    CAS  PubMed  Google Scholar 

  • Dwoskin, L.P. and Zahniser, N.R. (1986). Robust modulation of [3H]dopamine release from rat striatal slices by D-2 dopamine receptors. J. Pharmacol. Exp. Ther., 239, 442–453.

    CAS  PubMed  Google Scholar 

  • Garey, R.E. and Heath, R.G. (1976). The effects of phencyclidine on the uptake of [3H]catecholamines by rat striatal and hypothalamic synaptosomes. Life Sci., 18, 1105–1110.

    Article  CAS  PubMed  Google Scholar 

  • Smith, R.C, Meitzer, H.Y., Arora, R.C. and Davis, J.M. (1977). Effects of phencyclidine on [3H]-catecholamine and [3H]-serotonin uptake in synaptosomal preparations from rat brain. Biochem. Pharmacol., 26, 1435–1439.

    CAS  Google Scholar 

  • Vickroy, T.W. and Johnson, K.M. (1982). Similar dopamine releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices. J. Pharmacol. Exp. Ther., 223, 669–674.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Copyright information

© 1988 Linda P. Dwoskin, Greg A. Gerhardt, Carla J. Drebing, Cindy C. Wilcox and Nancy R. Zahniser

About this chapter

Cite this chapter

Dwoskin, L.P., Gerhardt, G.A., Drebing, C.J., Wilcox, C.C., Zahniser, N.R. (1988). Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_42

Download citation

Publish with us

Policies and ethics