Effect of Methamphetamine on in vivo Release of Dopamine and its Metabolites from the Striatum in Freely Moving Rats

  • Hiroshi Watanabe
  • Shun-ichi Sekihara
  • Yasuyuki Nomura
Part of the Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology book series (SSNIC)

Abstract

Recently, a novel method of intracerebral microdialysis was devised to estimate the release of extracellular dopamine (DA) in brain regions simultaneously with behavioral alterations in awake animals (Ungerstedt, 1984). It has been reported that the intensity of stereotyped head and forepaw movements induced by amphetamine is correlated with the amount of DA released in the striatum (Sharp et al., 1987). To investigate a relationship of striatal DA release to methamphetamine-induced behavioral alterations, we have used trans-striatal dialysis of DA and its metabolites in freely moving rats.

Keywords

HPLC EDTA Dopamine Cage Amphetamine 

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References

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Copyright information

© Hiroshi Watanabe, Shun-ichi Sekihara and Yasuyuki Nomura 1988

Authors and Affiliations

  • Hiroshi Watanabe
    • 1
  • Shun-ichi Sekihara
    • 1
  • Yasuyuki Nomura
    • 2
  1. 1.Research Institute for Wakan-YakuToyama Medical and Pharmaceutical UniversityToyamaJapan
  2. 2.Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

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