Abstract
There are conflicting results regarding whether dopamine acts as an excitatory or inhibitory neurotransmitter on the caudate nucleus (CN) neurons; for instance, stimulation of the pars compacta of the substantia nigra (SN) produces EPSP and action potentials in the CN neuron, and these potentials are blocked by dopamine receptor antagonists, while iontophoretically applied dopamine depolarizes the membrane concomitant with an inhibition of spontaneous firing. In addition, iontophoretically applied dopamine usually inhibits spontaneous and glutamate-induced firing, although an increase in the firing is sometimes observed. These discrepant results are considered to be due to the action of dopamine on different receptors, which are adenylate cyclase-linked D-1 and unrelated D-2 receptors, since both receptors are known to be present in the CN. Therefore, electrophysiological studies using an iontophoretic technique in vivo and intracellular recording methods in vitro were performed to elucidate whether or not the D-1 receptor mediates the inhibitory effects and D-2 the excitatory actions, and to determine whether both D-1 and D-2 receptors coexist in the same CN neuron.
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Fujimoto, S., Sasa, M. and Takaori, S. (1981). Inhibition from locus coeruleus of caudate neurons activated by nigral stimulation. Brain Res. Bull., 6, 267–274.
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© 1988 Masashi Sasa, Akinori Akaike, Yukihiro Ohno, Yasuhiko Fujita and Shuji Takaori
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Sasa, M., Akaike, A., Ohno, Y., Fujita, Y., Takaori, S. (1988). Inhibition and Excitation Mediated Respectively by Dopamine D-1 and D-2 Receptors on the Caudate Nucleus Neurons Receiving Dopaminergic Input from the Substantia Nigra: Microiontophoretic and in vitro Studies. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_36
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DOI: https://doi.org/10.1007/978-1-349-10047-7_36
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-10049-1
Online ISBN: 978-1-349-10047-7
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