Functional Specificity of Nigral Grafts in Dopamine-depleted Rats
In 1979, two independent research groups first reported that embryonic dopamine cells transplanted to the forebrain of dopamine-depleted rats could exert a functionally beneficial influence on the behavioural deficits of the host animals (Bjorklund and Stenevi, 1979; Perlow et al., 1979). In the intervening years there have been many reports of the functional capacity of neural grafts in a number of different model systems (Bjorklund and Stenevi, 1985). However, dopamine lesions and grafts remain the most widely studied functional model system in rodents, and preliminary studies of functional benefits have also been reported in monkeys (Redmond et al., 1986).
KeywordsDopamine Cage Tyrosine Serotonin Noradrenaline
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