Abstract
Several recent studies have addressed the functional inter- vs. independence of central DA D-1 and D-2 receptor sites. D-1 and D-2 agonists generally appear synergistic in producing postsynaptic behavioural effects, and there is evidence to suggest that the simultaneous activation of both D-1 and D-2 receptors is required to achieve optimal motor stimulation in normosensitive rats (e.g. Walters et al. 1987). D-1/D-2 agonist interaction studies have, however hitherto been limited to conventional, “non-selective” D-2 agonists — capable of activating DA autoreceptors as well as postsynaptic DA receptors.
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© 1988 Stephan Hjorth and Arvid Carlsson
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Hjorth, S., Carlsson, A. (1988). D-1 Agonist Co-treatment Uncovers Postsynaptic Dopamine (DA) Receptor Stimulatory Properties of B-HT 920, a Putative DA (D-2) Autoreceptor-selective Agonist. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_30
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DOI: https://doi.org/10.1007/978-1-349-10047-7_30
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