Abstract
Typical dopamine (DA) receptor agonists are known to reduce the metabolism and synthesis of dopamine (DA) (Carlsson, 1975) as well as the firing activity of DA-neurons (Aghajanian and Bunney, 1977) and to influence motor activity in a biphasic inhibitory-stimulatory man ner (Di Chiara et al., 1976; Strömbom, 1976). According to current belief the inhibitory effects of DA-agonists on motor activity are related to stimulation of DA-receptors located on the DA-neuron itself and inhibiting neurotransmitter release and neuronal activity (DA-autoreceptors). However, in spite of the large number of studies performed on this subject, none of them has estimated the effect of DA-agonists on the release and metabolism of DA in freely moving animals. Here we report the effect of various DA-receptor agonists provided with different specificity and intrinsic activity for different DA-receptor subtypes on the release of DA, studied by brain dialysis, and on motor activity in behaving rats (Imperato and Di Chiara, 1984, 1985, 1986).
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© 1988 G. Di Chiara, A. Mulas and A. Imperato
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Di Chiara, G., Mulas, A., Imperato, A. (1988). Use of Brain Dialysis in Freely Moving Rats for Characterizing the Profile of Dopamine-receptor Agonists. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_28
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DOI: https://doi.org/10.1007/978-1-349-10047-7_28
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