Abstract
Electrophysiological studies of the dopamine-containing neurones of the substantia nigra zona compacta in vivo have demonstrated that the rate of action potential discharge is reduced by dopamine and apomorphine (Bunney et al., 1973). This effect is mimicked by amphetamine (which releases dopamine, probably from dendritic sites within the substantia nigra) and blocked by neuroleptic drugs (Groves et al., 1975). These observations have given rise to the concept of ‘autoinhibition’ of these neurones whereby their firing rate, and also their release of transmitter, is inhibited as a result of dopamine acting upon ‘autoreceptors’ on the same neurones from which it is released.
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© 1988 M.G. Lacey, N.B. Mercuri and R.A. North
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Lacey, M.G., Mercuri, N.B., North, R.A. (1988). D2 Receptor Activation Increases Potassium Conductance in Substantia Nigra Zona Compacta Neurones in vitro. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_12
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DOI: https://doi.org/10.1007/978-1-349-10047-7_12
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