Abstract
The signal transduction mechanisms mediating the effects of dopamine are not fully elucidated. Several pieces of evidence support the concept that activation of the dopamine D-2 receptor in the neostriatum and in the anterior pituitary gland decreases adenylate cyclase (AC) activity (Enjalbert and Bockaert, 1983; Seeman and Grigoriadis, 1987; Stoof and Kebabian, 1981; Trabucchi et al., 1975). However, in more recent experiments the stimulation of the D-2 receptor was not followed by a decrease in the cyclic AMP (cAMP) level. As an example, the inhibition of the neurotensin-induced calcium influx and prolactin release in lactotrophic cells as well as the inhibition of K+-evoked dopamine release from striatal slices, both mediated by D-2 receptor stimulation, are not accompanied by changes in the cAMP levels (Memo et al., 1986a; 1986b). These findings suggest the possibility that D-2 receptors could be linked to a second messenger generating system different from the CA. For instance recent studies with striatal tissue and cells of the anterior pituitary provided evidence that dopamine, by acting at D-2 receptor sites, inhibits both AC activity (Enjalbert et al., 1986; Stoof and Kebabian, 1981) and polyphosphoinositide (PPI) breakdown. However, in a recent study with anterior pituitary cells dopaminergic stimulation did not attenuate phosphoinositide hydrolysis (Canonico et al., 1986).
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References
Abdel-Latif, A.A. (1986). Calcium mobilizing receptors polyphosphoinositides and the generation of second messengers. Pharmacol. Rev., 38, 227–273.
Baudry, M., Evans, J. and Lynch, G. (1986). Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus. Nature, 319, 329–331.
Berridge, M.J., Dawson, R.M.C., Downes, C.P., Heslop, J.P. and Irvine, R.F. (1983). Changes in the levels of inositol phosphates after agonist dependent hydrolysis of membrane phosphoinositides. Biochem. J., 212, 473–482.
Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248–254.
Brown, E., Kendall, D.A. and Nahorski, S.R. (1984). Inositol phospholipidis hydrolysis in rat cerebral cortical slices: I. Receptor characterization. J. Neurochem., 42, 1379–1387.
Canonico, P.L., Jarvis, W.D., Judd, A.M. and MacLeod, R.M. (1986). Dopamine does not attenuate phosphoinositide hydrolysis in rat anterior pituitary cells. J. Endocr., 110, 389–393.
Cote, E., Greve, C.W., Tsuruda, K., Stoff, J.C. and Eskay, R.L. (1982). D-2 dopamine receptor-mediated inhibition of adenylate cyclase activity in intermediate lobe of the rat pituitary gland requires guanosine 5′-triphosphate. Endocrinology, 110, 812–819.
Enjalbert, A. and Bockaert, J. (1983). Pharmacological characterization of the D-2 dopamine receptors negatively coupled with adenylate cyclase in rat anterior pituitary. Mol. Pharmacol., 23, 576–584.
Enjalbert, A., Sladeczek, F., Guillon, G., Bertrand, P., Shu, C., Epelbaum, J., Garcia-Sainz, A., Jard, S., Lombard, C., Kordon, C. and Bockaert, J. (1986). Angiotensine II and dopamine modulate both cAMP and inositol phosphate production in anterior pituitary cell. J. Biol. Chem., 261, 4071–4075.
Hallcher, L.M. and Sherman, W.R. (1980) The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphate from bovine brain. J. Biol. Chem., 255, 10896–10901.
Hawkins, P.T., Stephens, L. and Downes, C.P. (1986). Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate. Biochem. J., 238, 507–516.
Hyttel, J. (1983). SCH 23390: the first selective dopamine D-1 antagonist. Eur. J. Pharm., 91, 153–154.
Irvine, R.F., Angard, E.E., Letcher, A.J. and Downes, C.P. (1985). Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands. Biochem. J., 229, 505–511.
Irvine, R.F., Letcher, A.J., Heslop, J.P. and Berridge, J.J. (1986). The inositol tris/tetrakisphosphate pathway-demonstration of Ins (1,4,5)P3 3-kinase activity in animal tissues. Nature, 320, 631–634.
Mejerus, P.W., Connolly, T.M., Deckmyn, H., Ross, T.S., Bross, T.E., Ishii, H., Bansal, V.S. and Wilson, D.B. (1987). The metabolism of phosphoinositide-derived messenger mclecules. Science, 234, 1519–1526.
Memo, M., Missale, C., Carruba, M.O. and Spano, P.F. (1986a). D-2 dopamine receptors associated with inhibition of dopamine release from rat neostriatum are independent of cyclic AMP. Neurosci. Lett., 71, 192–196.
Memo, M., Castelletti, L., Missale, C., Carruba, M.O. and Spano, P. F. (1986b). Dopaminergic inhibition of prolactin release and calcium influx induced by neurotensin in anterior pituitary is independent of cyclic AMP system. J. Neurochem., 47, 1689–1695.
Onali, P.L., Olianas, M.C. and Gessa, G.L. (1985). Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum. Molec. Pharmac., 28, 138–145.
Pizzi, M., d’Agostini, F., Da Prada, M., Spano, P.F. and Haefely, W.E. (1987). Dopamine D-2 receptor stimulation decreases the inositol trisphosphate level of rat striatal slices. Eur. J. Pharm., 136, 263–264.
Pugh, M.T., O’Boyle, K.M., Molloy, A.G. and Waddington, J.L. (1985). Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU 24213. Psychopharmacology, 87, 308–312.
Seeman, P. and Grigoriadis, D. (1987). Dopamine receptors in brain and periphery. Neurochem. Int., 10, 1–25.
Senogles, S.E., Benovic, J.L., Amlaiky. N., Unson, C., Milligan, G., Vinitsky, R., Spiegel, A.M. and Caron, M.G. (1987). The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. J. Biol. Chem., 262, 4860–4867.
Sibley, D.R., Leff, S.E. and Creese, I. (1982). Interactions of novel dopaminergic ligands with D-1 dopamine receptors. Life Sci., 31, 637–645.
Simmond, S.H. and Strange, P.G. (1985). Inhibition of inositol-phospholipid breakdown by D-2 dopamine receptors in dissociated bovine anterior pituitary cells. Neurosci. Lett., 60, 267–272.
Stoof, J.C. and Kebabian, J.W. (1981). Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature, 294, 366–368.
Trabucchi, M., Longoni, R., Fresia, P. and Spano, P.F. (1975). Sulpiride: a study of the effects on dopamine receptors in rat neostriatum and limbic forebrain. Life Sci., 17, 1551–1556.
Yukihiro, O., Sasa, M. and Takaori, S. (1986). Excitation by dopamine D-2 receptor agonists, bromocriptine and LY 171555, in caudate nucleus neurons activated by nigral stimulation. Life Sci., 38, 1867–1873.
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© 1988 M. Da Prada, M. Pizzi, A. Valerio, M. Memo, P.F. Spano and W.E. Haefely
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Da Prada, M., Pizzi, M., Valerio, A., Memo, M., Spano, P.F., Haefely, W.E. (1988). Dopamine D-2 Receptor Agonists Decrease the Basal Level of Inositol 1,4,5-Trisphosphate in Rat Striatal Slices. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_11
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