Abstract
The rigidity of a calcified tissue derives almost entirely from its mineral content. This means that information about the mineral distribution is fundamental to the understanding of its mechanical properties. Changes in the mineral content can occur in diseases such as osteoporosis, a common condition of postmenopausal women where mineral loss from bones predisposes them to fracture. The changes that can occur in this and other conditions of bone can be due to volume changes in the amount of mineralised tissue and/or changes in the degree of mineralisation of that tissue. Thus changes in gross mineral density alone give a very incomplete picture. What is required is the complete three-dimensional distribution at a microscopic level.
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Elliott, J.C., Anderson, P., Boakes, R., Dover, S.D. (1989). Scanning X-ray microradiography and microtomography of calcified tissues. In: Hukins, D.W.L. (eds) Calcified Tissue. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-09868-2_3
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DOI: https://doi.org/10.1007/978-1-349-09868-2_3
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