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The Role of Extracellular Matrix in Development

  • Chapter
Connective Tissue Matrix

Part of the book series: Topics in Molecular and Structural Biology ((TMSB))

Abstract

The main roles of the extracellular matrix (ECM) in the mature animal are to maintain the integrity and strength of organs and to provide the structural components of tissues such as bone, cartilage and tendon. In the developing embryo, however, ECM not only participates in the morphogenesis of these tissues, but also has a series of other functions. There is now information showing that ECM provides an environment through which cells can migrate, provides a substratum for their adhesion and guidance and can provide stability to tissues in the process of formation. It can also create spaces, control growth and influence cell differentiation. ECM thus has a particularly interesting contribution to make to the emergence of structure in the embryoone that is far richer than is apparent from our knowledge of the roles of ECM in mature tissue.

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Authors
  1. Jonathan B. L. Bard
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Editors and Affiliations

  1. Department of Medical Biophysics, University of Manchester, UK

    David W. L. Hukins

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© 1990 The Macmillan Press Ltd

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Bard, J.B.L. (1990). The Role of Extracellular Matrix in Development. In: Hukins, D.W.L. (eds) Connective Tissue Matrix. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-09865-1_2

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  • DOI: https://doi.org/10.1007/978-1-349-09865-1_2

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-09867-5

  • Online ISBN: 978-1-349-09865-1

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