Abstract
Administration of drugs by conventional means results in their general distribution throughout the body. With drugs of low toxicity this is of little clinical significance, but where the therapeutic ratio is small, some attempt to minimise toxicity must be made. One approach is to use carrier systems which will transport the drug to specific target organs or, ideally, to sites of action within these organs (Borchardt et al., 1985; Tomlinson and Davis, 1986). This approach relies on the special transport and uptake processes that can be utilised when a drug is encapsulated within colloidal carriers or attached to macromolecules which are handled and distributed within the body differently from low molecular weight drugs in free form which with the appropriate lipophilic character diffuse readily across barrier.
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© 1988 Bioengineering Unit, University of Strathclyde
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Florence, A.T., Baillie, A.J., Halbert, G.W., Willmott, N. (1988). Carrier Systems for Drug Delivery and Targeting: Protein Microspheres, Niosomes and LDL Particles. In: Paul, J.P., McCruden, A.B., Schuetz, P.W. (eds) The Influence of New Technology on Medical Practice. Keynes Seminars. Palgrave, London. https://doi.org/10.1007/978-1-349-09609-1_34
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DOI: https://doi.org/10.1007/978-1-349-09609-1_34
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