Cloning and Sequencing of Murine Lupus-Associated Autoantibody Genes
Arc there any primary structures common to ail AAb regardless of their specificity, which might signal their autoreactive nature?
Do AAb employ Ig genes in a restricted manner and are there unique Ig genes different from the germline pool used in the response to exogenous antigens?
To what extent is self-specificity germline encoded or acquired during B-cell development?
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