Abstract
There is considerable evidence that disturbances in the mechanisms controlling circadian rhythms play an important part in the aetiology of depression (Hallonquist et al., 1986). For instance, Carrol et al. (1976) reported that 88% of bipolar and 50% of unipolar depressives demonstrated early escape from overnight dexamethasone suppression. Wehr et al. (1983) suggested that this phenomenon could be explained by a resetting of the ‘biological clock’. Thus if, as they observed, circadian rhythms of depressives are phase-advanced compared with control subjects, one might expect an early escape since the drug will have been given later in the circadian cycle of the depressives.
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Martin, K.F., Marsden, C.A. (1988). In-vivo Identification of the Serotonin (5-HT) Autoreceptor in the Rat Suprachiasmatic Nucleus (SCN). In: Briley, M., Fillion, G. (eds) New Concepts in Depression. Palgrave, London. https://doi.org/10.1007/978-1-349-09506-3_5
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