Abstract
Hyperthermia induced by the 5-hydroxytryptamine (5-HT) releaser parachloro amphetamine (PCA) in heat-adapted rats is prevented not only by 5-HT receptor blockers or blockers of 5-HT synthesis, but also by membrane-active drugs such as the antidepressants clomipramine, citalopram and zimelidine which are potent 5 HT uptake inhibitors (Frey, 1975; Pawłowski et al., 1980; Pawłowski, 1981). Since clomipramine and citalopram do not prevent the hyperthermia induced by quipazine, a direct 5-HT receptor agonist (Pawłowski, 1984), it may be suggested that the PCA-induced hyperthermia is a good in-vivo test for 5-HT uptake inhibitors. It is frequently assumed that the latter drugs block the entrance of 5-HT releasing agents (e.g. PCA) into 5-HT neurons by inactivation of the specific carrier system for 5-HT which – at the same time – operates also for these agents (Fuller, 1980).
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Pawłowski, L. (1988). Effects of the Membrane-active Antidepressant Drugs, Selective 5-HT or NA Uptake Inhibitors, on p-Chloroamphetamine (PCA)-induced Hyperthermia in Heat-adapted Rats. In: Briley, M., Fillion, G. (eds) New Concepts in Depression. Palgrave, London. https://doi.org/10.1007/978-1-349-09506-3_17
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DOI: https://doi.org/10.1007/978-1-349-09506-3_17
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