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The Vascular (DA1) Dopamine Receptor

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Peripheral Actions of Dopamine

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Abstract

Investigation of the unusual cardiovascular effects of DA by Goldberg and colleagues in the 1960s led to the hypothesis of a specific DA receptor which mediated vasodilatation in the renal and mesenteric vascular beds of the dog (Goldberg, 1972). In the 1970s the action of drugs on the postganglionic sympathetic nerves modulating the release of the transmitter via the presynaptic receptors was discovered (Langer, 1977, 1980; Starke, 1977). In the course of the investigation of presynaptic alpha-adrenoceptors, Langer (1973) and McCulloch et al. (1973) obtained evidence for the presence of specific DA receptors on sympathetic nerve terminals.

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Authors
  1. Jai D. Kohli
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  2. Leon I. Goldberg
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Melbourne Medical Centre, Australia

    Christopher Bell

  2. Department of Medicine, Monash University Medical Centre, Australia

    Barry McGrath

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© 1988 Jai D. Kohli and Leon I. Goldberg

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Kohli, J.D., Goldberg, L.I. (1988). The Vascular (DA1) Dopamine Receptor. In: Bell, C., McGrath, B. (eds) Peripheral Actions of Dopamine. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-09503-2_7

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  • DOI: https://doi.org/10.1007/978-1-349-09503-2_7

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-09505-6

  • Online ISBN: 978-1-349-09503-2

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